Experimental study on infusion devices containing polyvinyl chloride: To what extent are they di(2-ethylhexyl)phthalate-free?

Genay, Stéphanie; Luciani, Chiara; Décaudin, Bertrand; Kambia, Nicolas; Dine, T.; Azaroual, Nathalie; Martino, Piera Di; Barthélémy, Christine; Odou, Pascal

doi:10.1016/j.ijpharm.2011.03.060

Cited by 43 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A better understanding of the human metabolism and excretion kinetics of these plasticizers is crucial for identifying metabolites whose harmlessness could be compromised. Indeed, the distribution of the replacement plasticizers is not homogeneous in MDs, as indicated by some studies 15,29 . For this reason, in situations classified ''at risk'', bio-monitoring studies will allow assessing the levels of these chemicals and/or metabolites in fluids like blood, urine or expired air in order to predict the potential risk of human exposure as well as health risk.…”

Section: Resultsmentioning

confidence: 98%

“…Indeed, a wide range of substances, both natural and manmade, are thought to cause endocrine disruption: dioxin and dioxin-like compounds, polychlorinated biphenyls and other pesticides, components of plastics such as bisphenol A and phthalates 10 . Phthalates, as endocrine disruptors have been identified as reproductive and developmental toxicants, though their toxicity varies somewhat depending on the specific phthalate structure The 2008 report by the Scientific Committee on Emerging and Newly-Identified Health Risks (SCENIHR) highlighted DEHP toxicity from several animal and some human studies and also suggested using less-toxic alternatives 15 . Following these considerations, the use of MDs containing phthalates including DEHP has recently been challenged by European directive 2007/47/EC, effective since March 2010 16 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Kambia

Farce

Bélarbi

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

Phthalates, used in medical devices (MDs), have been identified as reproductive and developmental toxicants. Their toxicity varies somewhat depending on the specific phthalate and is in part linked to the activation of Peroxisome Proliferating-Activated Receptors (PPARs). So, the use of MDs containing targeted phthalates such as di(2-ethylhexyl) phthalate (DEHP) has been challenged by European directive 2007/47/EC. Therefore, MDs manufacturers were forced to quickly find replacement plasticizers. However, very little toxicological and epidemiological studies are available on human health. So, we proceeded to dock these chemicals in order to identify compounds that are likely to interact with PPARs binding sites. The results obtained are generally very mixed on the harmlessness of these alternatives. Moreover, no data exist on the biological effects of their possible metabolites. As DEHP toxicity resulted mainly from its major metabolites, generalizing the use of these plasticizers without conducting extensive studies on the possible effects on human health of their metabolites seems inconceivable.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Kambia

Farce

Bélarbi

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Very low migration rates have been found for TOTM from PVC tubes into enteral feeding solutions when compared to DEHP or DEHA (Welle et al, 2005). However, the tubes often show impurities with DEHP (Genay et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3)

Fromme

Schütze

Lahrz³

et al. 2016

International Journal of Hygiene and Environmental Health

110

View full text Add to dashboard Cite

“…Tris(2-ethylhexyl) trimellitate or 1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) ester commonly known as TOTM, is about two times more viscous than DIDP and is one of the most used plasticizers in the polymer industry, which makes it available throughout the world [35,36]. It is used as plasticizer for flexible and high temperature resistant PVC products, and its utilization seems to be expanding [35][36][37][38][39][40]. To our knowledge, although TOTM is classified as harmful in contact with skin, and susceptible to cause serious eye irritation, it is not classified as dangerous, according to European Directive 67/548/ EEC [41].…”

Section: Introductionmentioning

confidence: 99%

Tris(2-ethylhexyl) trimellitate (TOTM) a potential reference fluid for high viscosity. Part I: Viscosity measurements at temperatures from (303 to 373) K and pressures up to 65 MPa, using a novel vibrating-wire instrument

Diogo

Avelino

Caetano

et al. 2014

Fluid Phase Equilibria

View full text Add to dashboard Cite

A B S T R A C TThe article reports viscosity measurements of compressed liquid tris(2-ethylhexyl) trimellitate or 1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) ester (TOTM) which is an important plasticizer in the polymer industry and has wide applications as a lubricant. Nevertheless, the main motivation for the present work is to propose TOTM as a plausible candidate for an industrial viscosity reference fluid for high viscosity, high pressure and high temperature. This kind of reference fluid is presently on demand by oil industries and the International Association for Transport Properties is developing efforts aiming to select appropriate candidates and to establish the corresponding reference data.The viscosity measurements were performed with a novel vibrating wire sensor. The new instrument was designed for operation at high pressures (up to 100 MPa) and temperatures up to 373 K. The present measurements were obtained using the vibrating wire sensor in the forced oscillation or steady-state mode of operation. The viscosity measurements were carried out up to 65 MPa and at six temperatures from (303 to 373) K.The viscosity results were correlated with density, using a modified hard-spheres scheme. The root mean square deviation of the data from the correlation is 0.53% and the maximum absolute relative deviation was less than 1.7%. The expanded uncertainty of the present viscosity results, at a 95% confidence level, is estimated to be less than AE2% for viscosities up to 68 mPa s, less than AE2.6% for viscosities between (69 and 268) mPa s and less than AE3% for higher viscosities.The TOTM density data necessary to compute the viscosity results were measured using a vibrating Utube densimeter, model DMA HP and are described in part II of the present work.No literature data above atmospheric pressure could be found for the viscosity of TOTM. As a consequence, the present viscosity results could only be compared upon extrapolation of the vibrating wire data to 0.1 MPa. Independent viscosity measurements were performed, at atmospheric pressure, using an Ubbelohde capillary in order to compare with the vibrating wire results, extrapolated by means of the above mentioned correlation. The two data sets agree within AE1%, which is commensurate with the mutual uncertainty of the experimental methods. Comparisons of the literature data obtained at atmospheric pressure with the present extrapolated vibrating-wire viscosity measurements have shown an agreement within AE2% for temperatures up to 339 K and within AE3.3% for temperatures up to 368 K.

show abstract

Experimental study on infusion devices containing polyvinyl chloride: To what extent are they di(2-ethylhexyl)phthalate-free?

Cited by 43 publications

References 20 publications

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Non-phthalate plasticizers in German daycare centers and human biomonitoring of DINCH metabolites in children attending the centers (LUPE 3)

Tris(2-ethylhexyl) trimellitate (TOTM) a potential reference fluid for high viscosity. Part I: Viscosity measurements at temperatures from (303 to 373) K and pressures up to 65 MPa, using a novel vibrating-wire instrument

Contact Info

Product

Resources

About