Experimental Study of Ulcerogenic Action of Propoxazepam

Abstract

In experiments on 94 white male rats in the Wistar line, were studied changes in the gastric mucous under the acute, subchronic and chronic conditions after introduction of a new original derivative of benzodiazepine – proxazepam. The study of gastrotoxicity of propoxazepam was carried out under conditions of its intragastric administration with Tween-80 solvents and distilled water. It has been established that propoxazepam does not exhibit a damaging effect on the stomach in the conditions of acute (3 hours after, 50, 250, 500 and 1000 mg/kg perorally), as well as subacute (within 4 days, 50 mg/kg perorally) and chronic (within 28 days, 0,5 mg/kg perorally) administration, and also does not change the dietary behavior and general activity of animals, which is confirmation of harmlessness of this compound, in particular, on the gastrointestinal tract.

Physiological aspects of rat activity, their anxiety and memory after administration of full gabaa-receptor complex agonist propoxazepam

“…Propoxazepam also has no detrimental effect on the stomach under conditions of acute, subacute and chronic administration and does not change the eating behaviour and general activity of animals, which is evidence of the safety of this compound, in particular, for the gastrointestinal tract [9].…”

Пропоксазепам — Новаторський Анальгетичний Засіб, Що Гальмує Гострий Та Хронічний Біль І Має Полімодальний Механізм Дії

“…Відповідно до регламентованих вимог доклінічних досліджень, визначено гостру токсичність та токсичність за повторних (90 днів) введень пропоксазепаму щурам [47], його гастротоксичну дію [48], стан клініко-лабораторних і морфологічних показників внутрішніх органів щурів [49], а також алергізувальну, геннотоксичну та канцерогену дії [50]. Отримані результати свідчать про відсутність значних відхилень показників від контрольних.…”

Dose and time-dependent acute and subchronic oral toxicity study of propoxazepam in mice and rats

“…Our data suggest that the mechanism of propoxazepam anticonvulsant properties includes GABAergic and glycinergic systems . Antibradykinin and antileukotriene action, dopaminergic system, NMDA, and alpha-1 adrenergic receptors, except the antiprostaglandin component, are involved in the mechanisms of propoxazepam analgesic effect (Voloshchuk et al, 2018). In order to explore clinical potential of propoxazepam for long term human administration, toxicology testing in laboratory animals using well-accepted international guidelines is required.…”