Experimental study of single-plate EWOD device for a droplet based PCR system

Ugsornrat, Kessararat; Maturos, Thitima; Pogfai, Tawee; Wisitsoraat, Anurat; Lomas, Tanom; Tuantranont, Adisorn

doi:10.1109/ecticon.2011.5947756

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Droplets may be stored on an electrode or they can be entered from dispensing ports and output to reservoirs. In addition, some operations such as detection and heating can be performed by devising various sensors, cameras and heating elements [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Improved experimental time of ultra‐large bioassays using a parallelised microfluidic biochip architecture/scheduling

Taajobian

Jahanian

2018

IET nanobiotechnol.

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Digital microfluidic is an emerging technology to reduce the cost and time of experiments and improve the flexibility, automate-ability and correctness of biochemical assays. In many of applications such as drug discovery and DNA profiling, a large number of bio-operations (e.g. the chemical operations used in biology applications) must be done. In these applications, parallelising the operations will be critical in accuracy and cost of the process and digital microfluidic biochips can be considered as a reasonable platform. In this study, a new microfluidic architecture and the corresponding CAD flow is introduced to parallelise the assays on this platform. The authors implemented the proposed architecture and evaluated it using the large real bioassays. The authors' simulations show that the degree-of-parallelism and speed of bioassays are increased more than 4× and the improvements will be better for larger assays. This contribution can open new horizons in drug testing, biology experiments and medical diagnosis operations that contain iterative, time-consuming and labour experiments.

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Section: Introductionmentioning

confidence: 99%

Improved experimental time of ultra‐large bioassays using a parallelised microfluidic biochip architecture/scheduling

Taajobian

Jahanian

2018

IET nanobiotechnol.

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“…In addition to droplet transport, splitting, merging and mixing, droplets can be stored on an electrode and input/output from/to reservoirs. Furthermore, individual cells can be equipped with various sensors, cameras and heating elements to perform detection and heating operations [6] [11]. These basic operations have been shown adequate to perform an assortment of assays such as in-vitro diagnostics and immunoassays used in clinical pathology [9], DNA polymerase chain reaction (PCR) mixing stages used to amplify DNA [3] and protein crystallizations [12].…”

Section: Introductionmentioning

confidence: 99%

Path scheduling on digital microfluidic biochips

Grissom

Brisk

2012

Proceedings of the 49th Annual Design Automation Conference

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Since the inception of digital microfluidics, the synthesis problems of scheduling, placement and routing have been performed offline (before runtime) due to their algorithmic complexity. However, with the increasing maturity of digital microfluidic research, online synthesis is becoming a realistic possibility that can bring new benefits in the areas of dynamic scheduling, control-flow, fault-tolerance and live-feedback. This paper contributes to the digital microfluidic synthesis process by introducing a fast, novel path-based scheduling algorithm that produces better schedules than list scheduler for assays with high fan-out; path scheduler computes schedules in milliseconds, making it suitable for both offline and online synthesis.

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Integrated CMOS Polymerase Chain Reaction Lab-on-chip

Norian¹

2014

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Experimental study of single-plate EWOD device for a droplet based PCR system

Cited by 3 publications

References 6 publications

Improved experimental time of ultra‐large bioassays using a parallelised microfluidic biochip architecture/scheduling

Improved experimental time of ultra‐large bioassays using a parallelised microfluidic biochip architecture/scheduling

Path scheduling on digital microfluidic biochips

Integrated CMOS Polymerase Chain Reaction Lab-on-chip

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