Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis

Zelchan, Roman; Медведева, А. А.; Синилкин, И. Г.; Bragina, Olga; Чернов, В. И.; Stasyuk, E. S.; Рогов, А. С.; Ilina, E. A.; Larionova, L. A.; Скуридин, В. С.; Дергилев, А. П.

doi:10.1088/1757-899x/135/1/012054

Cited by 14 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 F, созданный нами препарат 99m Тс1тиоDглюкоза поступает в клетку с помощью белкапереносчи-ка глюкозы 1 типа (GLUT1), но не подвергается фосфорилированию (рис. 6) [16,17]. Диагностическим преимуществом 99m Тс1 тиоDглюкозы является отсутствие физиологического накопления в головном мозге (рис.…”

Section: Doi: 1037174/258775932020342638unclassified

Innovative Radiopharmaceuticals for Cancer Diagnosis and Treatment

Чернов

Медведева

Zelchan

et al. 2020

jour

View full text Add to dashboard Cite

The presented material summarizes the experience of Cancer Research Institute and Tomsk Polytechnical University team in the development of original radiopharmaceuticals (RP) for nuclear medicine. The first such unique for world nuclear medicine RP was a Thallium199. The Thallium199 is successfully used for breast cancer diagnosis and its lymphogenous metastasis, as well as to visualize cancer of the larynx and laryngopharynx, their relapses and for differential diagnosis of inflammatory and tumor processes of the musculoskeletal system. The great practical importance for nuclear medicine has the organization of a wastefree production of sorption and extraction generators of Technetium-99m at the IRTT TPU nuclear research reactor, as well as the creation of a fully automated 99mTc module operating on a waste free technology. The development of the 99mTcAlotech for targeting imaging of sentinel lymph nodes (SLN) has also great importance for clinical oncology. The main advantage of 99mTcGlucoscin is that metabolic tumor imaging with the innovative RP use can be performed using a conventional gamma camera, which significantly reduces the cost of the diagnostic procedure. The present and promising developments of the research teams of the Tomsk Scientific Research Center and the Tomsk Polytechnic University are closely related to theranostics — the use of RPs obtained on the basis of same target compound labeled with different isotopes intended for the diagnosis or therapy of oncological diseases.

show abstract

Section: Doi: 1037174/258775932020342638unclassified

Innovative Radiopharmaceuticals for Cancer Diagnosis and Treatment

Чернов

Медведева

Zelchan

et al. 2020

jour

View full text Add to dashboard Cite

show abstract

“…Одним из таких перспективных индикаторов может стать 99m Tc-1-Тио-D-глюкоза ( 99m Тс-ТГ). Препарат был разработан в Томском НИМЦ и Томском политехническом университете, он не обладает токсичностью, кумулятивностью, аллергизирующими свойствами и характеризуется высокой аккумуляцией в опухолевых клетках in vivo и in vitro [61][62][63][64][65][66][67][68][69][70][71]. Проведены первые клинические исследования этого РФП, показавшие перспективность его использования для диагностики злокачественных процессов [72].…”

Section: пэт C 18 F-фдг в оценке результатов лечения метастазов печениunclassified

The Value of Pet/Ct in the Diagnosis, Stading and Monitoring of Colorectal Cancer

et al. 2019

View full text Add to dashboard Cite

The purpose of the study was to provide up-to-date data on the efficacy of positron emission computed tomography (PET) for the diagnosis, assessment of tumor extension and monitoring of colorectal cancer.Material and Methods. The Medline and Pubmed databases were used for searching for publications devoted to clinical trials of diagnostic value of PET with 18F-Ftordesoxyglucose (PET with 18F-FDG).Results. Data on the value of PET with 18F-FDG in visualization of the primary tumor, detection of lymph node and distant metastases and assessment of the treatment response in patients with colorectal cancer were presented.Conclusion. PET with 18F-FDG was shown to be a promising imaging method for colorectal cancer. It is the most sensitive method in the detection of liver metastases. 18F-FDG PET is particularly superior to CT and MET in the ability to assess tumor response to treatment and predict early tumor response to therapy. The development of new radiopharmaceuticals for the diagnosis, staging, monitoring and prediction of colorectal cancer is of great importance.

show abstract

“…It was proved that 99m Tc-TG was characterized by high accumulation in tumor cells in vivo and in vitro [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The First Experience of Using 99mtc-1-Thio-D-Glucose for Single-Photon Emission Computed Tomography Imaging of Lymphomas

Чернов¹,

Dudnikova²,

Zelchan³

et al. 2018

Sib. onkol. ž.

View full text Add to dashboard Cite

Introduction. The purpose of this study was to evaluate the feasibility of using 99mTc-TG SPECT in the detection and staging of malignant lymphoma.Materials and methods.Fifteen patients with newly diagnosed malignant lymphoma underwent 99mTc-TG SPECT. Six patients had Hodgkin’s lymphoma and 9 patients had aggressive forms of non-Hodgkin’s lymphoma (NHL): diffuse large B-cell lymphoma (7 cases), B-cell follicular lymphoma (1 case), and lymphoma from B cells in the marginal zone (1 case). Stage IIA was diagnosed in 5 patients, stage IIB in 1, stage IIIA in 1, stage IVA in 4 and stage IVB in 4 patients.Results.Pathological 99mTc-TG uptake in lymph nodes was observed in 14 (93 %) of the 15 patients. In one patient, the enlarged submandibular lymph node (16 mm in size) detected by CT was not visualized by 99mTc-TG SPECT. This false-negative result was likely to be associated with increased accumulation of 99mTc-TG in the oropharyngeal region. There were difficulties in the visualization of paratracheal, para-aortic and paracardial lymph nodes. These difficulties were associated with a high blood background activity, which persisted even 4 hours after intravenous injection of 99mTc-TG. Software-based SPECT and CT image fusion allowed visualization of these lymph nodes. The pathological 99mTc-TG accumulation in axillary, supraclavicular, infraclavicular and cervical lymph nodes was observed most often. Extranodal involvement was seen in 9 patients. 99mTc-TG SPECT identified extranodal hypermetabolic lesions in 7 (78 %) of these patients. In one patient, hypermetabolic lesion in the lung detected by 99mTc-TG SPECT was not detected on CT image. CT identified bone marrow involvement in the pelvic and scapula in 1 patient. The use of 99mTc-TG SPECT allowed the visualization of hypermetabolic bone tissue lesions in this patient (Figure 4). In addition, in a patient with intact bone tissue on CT, 99mTc-TG SPECT detected hypermetabolic lesions in the iliac bone.Conclusion.99mTc-1-Thio-D-glucose demonstrated increased uptake in nodal and extranodal sites of lymphoma. The results indicate that SPECT with 99mTc-1-Thio-D-glucose is a feasible and useful tool in the detection and staging malignant lymphoma.

show abstract

Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis

Cited by 14 publications

References 5 publications

Innovative Radiopharmaceuticals for Cancer Diagnosis and Treatment

Innovative Radiopharmaceuticals for Cancer Diagnosis and Treatment

The Value of Pet/Ct in the Diagnosis, Stading and Monitoring of Colorectal Cancer

The First Experience of Using 99mtc-1-Thio-D-Glucose for Single-Photon Emission Computed Tomography Imaging of Lymphomas

Contact Info

Product

Resources

About