Experimental study of muscle permeability under various loading conditions

Nudel, Iftah; Hadas, Or; deBotton, Gal

doi:10.1007/s10237-019-01138-0

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Engineered tissue larger than these limits will result in necrosis of the tissue core. In vivo, the distribution of oxygen and nutrients in the muscle [ 181 ] and adaption to the acute needs of the organ are essential for muscle function and health [ 182 , 183 ]. Vascularization and perfusion of the tissue obtain a relevant role in fulfilling those needs [ 184 ].…”

Section: From 2d Cell Culture To Human Organs-on-a-chipmentioning

confidence: 99%

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease

Zschüntzsch¹,

Meyer²,

Shahriyari

et al. 2022

Cells

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Many neuromuscular disease entities possess a significant disease burden and therapeutic options remain limited. Innovative human preclinical models may help to uncover relevant disease mechanisms and enhance the translation of therapeutic findings to strengthen neuromuscular disease precision medicine. By concentrating on idiopathic inflammatory muscle disorders, we summarize the recent evolution of the novel in vitro models to study disease mechanisms and therapeutic strategies. A particular focus is laid on the integration and simulation of multicellular interactions of muscle tissue in disease phenotypes in vitro. Finally, the requirements of a neuromuscular disease drug development workflow are discussed with a particular emphasis on cell sources, co-culture systems (including organoids), functionality, and throughput.

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Section: From 2d Cell Culture To Human Organs-on-a-chipmentioning

confidence: 99%

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease

Zschüntzsch¹,

Meyer²,

Shahriyari

et al. 2022

Cells

View full text Add to dashboard Cite

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Viscoporoelasticity of coagulation blood clots

Kim²,

Ku³

et al. 2022

Extreme Mechanics Letters

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Next Stage Approach to Tissue Engineering Skeletal Muscle

et al. 2020

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Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process.

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Experimental study of muscle permeability under various loading conditions

Cited by 3 publications

References 21 publications

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease

The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease

Viscoporoelasticity of coagulation blood clots

Next Stage Approach to Tissue Engineering Skeletal Muscle

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