Viscoporoelasticity of coagulation blood clots

He, Dongjing; Kim, Dongjune; Ku, David N.; Hu, Yuhang

doi:10.1016/j.eml.2022.101859

Cited by 7 publications

(5 citation statements)

References 53 publications

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“…A blood clot, like most biological tissues, has both viscoelasticity and poroelasticity, and Ghezelbash et al [29] proved that blood clots are poroviscoelastic. According to He et al [28], the poroelastic and viscoelastic processes of a blood clot allow it to dissipate energy, which contributes to delaying the fracturing of the blood clot. In our proposed model, we analyze blood clots as a linear elastic solid using corresponding parameters of the clot, which allows us to calculate stresses influenced by the blood flow.…”

Section: Problem Formulationmentioning

confidence: 99%

“…Finally, we would like to discuss studies examining poro-viscoelastic behavior. The viscoporoelasticity of coagulated blood clots was investigated by He et al [28]. They argued that the particular viscoporoelastic properties of a coagulated blood clot can be related to many factors, such as the volume fraction of platelets, the fibrin concentration, the erythrocyte count, the thrombin concentration, and so on.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Analysis of Blood Clot Mechanical Behavior in Relation to Blood Flow Inside the Popliteal Vein

Brusokas,

Jasevičius

2024

Mathematics

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In this work, blood clot behavior under the influence of the mechanical effect of blood flow was analyzed. Attention is mainly paid to the deformation of the thrombus in the event of an alternating effect of blood flow in the blood vessel of the human leg. It is assumed that the higher stress accumulation is associated with a decrease in the width of the lumen of the blood vessel. The idea is to represent a critical case when embolus can form. The geometry of the thrombus is selected on the basis of existing blood patterns. Modeling is performed using COMSOL Multiphysics software. The results reflect the distribution of stress and blood velocity over time. The work selected a critical case, when the formation of an embolus is possible due to the deformation of the thrombus by the blood flow. Research is important for studying the behavior of thrombus formation at different periods of time, and also taking into account the specific geometry of thrombus deformation for the purpose of predicting embolisms. The results are observed due to increased deformations in the appropriate areas of the clot, whose tests show specific blood deformation from the alternating effects of blood on different sections of the vessels.

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Section: Problem Formulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Blood Clot Mechanical Behavior in Relation to Blood Flow Inside the Popliteal Vein

Brusokas,

Jasevičius

2024

Mathematics

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“…The mechanical property of soft tissue, as part of the biomechanics, has been studied for years, thus proposing various models, including viscoelastic, poroelastic, and biphasic theories. [26][27][28] Almost all biological soft tissues are viscoelastic materials, which produce not only an elastic response but also an increasing strain when subjected to compression, with highly nonlinear displacement mechanics. 29 In this study, only small deformations were applied to the soft tissue, and thus the complex hyperelasticity, which usually needs to be considered in large deformations, was not taken into account.…”

Section: Mechanical Modeling Of Soft Tissuementioning

confidence: 99%

Piezoresistivity modeling of soft tissue electrical-mechanical properties: A validation study

Guo

et al. 2023

Proc Inst Mech Eng H

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In general, the electrical property of soft tissues is sensitive to the force applied to their surface. To further study the relationship between the force and the electrical property of soft tissues, this paper attempts to investigate the effect of static and higher-order stresses on electrical properties. Overall, a practical experimental platform is designed to acquire the force information and the electrical property of soft tissues during a contact procedure, which is featured different compression stimuli, such as constant pressing force, constant pressing speed, and step-force compression, etc. Furthermore, the piezoresistive characteristic is innovatively introduced to model the mechanical-electrical properties of soft tissue. Finite Element Modeling (FEM) is adopted to fit the static piezoresistivity of the soft tissue. Finally, experimental studies were performed to demonstrate the effect of stress on the electrical properties and the feasibility of the proposed piezoresistive model to describe soft tissues’ mechanical and electrical properties.

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“…It is well established that a tight clot is responsible for reduced clot permeability and degradability that may be responsible for a high risk of deep vein thrombosis (DVT) and/or pulmonary embolism (PE) [ 1 , 2 , 3 ]. In addition, fibrin is a viscoelastic polymer that is under shear stress in the vessel due to blood flow [ 4 , 5 ]. The elasticity (or stiffness) is characterized by a reversible mechanical deformation, whereas the viscosity (or plasticity) is a slow irreversible deformation (creep).…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that a modification in the viscoelastic properties of the clot may induce a defective ability of the clot to deform in response to shear stress, contributing to clot embolization [ 15 ]. A stiff clot (large G′) deforms less than a softer clot with the same applied stress, and a dramatic increase in G′ is a contributing factor to thromboembolism [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Blood Clot Dynamics and Fibrinolysis Impairment in Cancer: The Role of Plasma Histones and DNA

Ullah,

Mirshahi,

Valinattaj Omran

et al. 2024

Cancers

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Background: Blood viscoelasticity and plasma protein levels can play an important role in the diagnosis and prognosis of cancer. However, the role of histones and DNA in modulating blood clot properties remains to be investigated. This study investigates the differences in blood viscoelasticity and plasma protein levels among cancer patients, individuals with other diseases, and healthy individuals. Methods: Blood samples were collected from 101 participants, including 45 cancer patients, 22 healthy individuals, and 34 individuals with other diseases. Rheological properties of clots formed in vitro by reconstituted elements of fibrinogen or plasma were analyzed with an Anton Paar Rheometer, USA. Plasma protein levels of D-dimer, TPA, EPCR, fibrinogen, and histone H3 were measured through ELISA. Blood clots were formed with or without DNA and histones (H3) by adding thrombin and calcium to plasma samples, and were evaluated for viscoelasticity, permeability, and degradation. Results: Cancer patients show higher blood viscoelasticity and plasma D-dimer levels compared to healthy individuals and individuals with other diseases. Our in vitro analysis showed that the addition of histone to the plasma results in a significant decrease in viscoelasticity and mean fiber thickness of the clot formed thereafter. In parallel studies, using plasma from patients, DNA and histones were detected in fibrin clots and were associated with less degradation by t-PA. Moreover, our results show that the presence of DNA and histones not only increases clots’ permeability, but also makes them more prone to degradation. Conclusions: Plasma histones and DNA affect the structure of the clot formed and induce defective fibrinolysis. Moreover, the increased viscoelastic properties of plasma from cancer patients can be used as potential biomarkers in cancer prognosis.

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Viscoporoelasticity of coagulation blood clots

Cited by 7 publications

References 53 publications

Numerical Analysis of Blood Clot Mechanical Behavior in Relation to Blood Flow Inside the Popliteal Vein

Numerical Analysis of Blood Clot Mechanical Behavior in Relation to Blood Flow Inside the Popliteal Vein

Piezoresistivity modeling of soft tissue electrical-mechanical properties: A validation study

Blood Clot Dynamics and Fibrinolysis Impairment in Cancer: The Role of Plasma Histones and DNA

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