Experimental Study of Bone Response to a New Surface Treatment of Endosseous Titanium Implants

Skeletal stem cell and bone implant interactions are enhanced by LASER titanium modification

“…The LASER treated surfaces in the current study, provide a topography that supported hSSC 1 viability and proliferation. A wealth of studies indicate rough Ti surfaces can enhance osseointegration in the clinic in comparison to smooth surfaces [6,7,12,22], although the cellular and molecular mechanisms that drive this process remain far from clear. ALP 6 activity is typically used as a marker to follow the differentiation of osteoblasts from non-calcium-depositing to calcium-depositing cells [23] , and as a marker of the early stages of osteogenic differentiation [24].…”

Osteoblastic cell behaviour on different titanium implant surfaces

“…Another method for roughening titanium implants uses a biocompatible and resorbable blasting material, such as biphasic calcium phosphate (BCP) ceramic particles [14]. As calcium phosphate materials are soluble in acids, they can be easily removed from the implant surface after blasting [15,16]. Furthermore, manufacturers claim that acid-etching produces nanometre-sized topography favourable for the adsorption of proteins and the attachment of osteoblastic cells [17][18][19][20].…”

The effect of pretreating resorbable blast media titanium discs with an ultrasonic scaler or toothbrush on the bacterial removal efficiency of brushing

“…The resorbable blast media (RBM) surface is prepared by sandblasting machined titanium with calcium phosphate ceramic media or hydroxyapatite particle-containing blast media [7,8]. The roughened RBM titanium surfaces exhibited better early cell attachment of osteoblast-like MG-63 cells than the smooth surfaces in the presence of serum [9], and the osteoblast-like MG-63 cells cultured on the RBM surfaces produced a greater amount of alkaline phosphatase than the cells cultured on smooth surfaces [10].…”