Experimental Studies on Treatment of Human Torulosis

Kligman, Albert M.

doi:10.1001/archderm.1949.01530050088008

Cited by 40 publications

(6 citation statements)

References 16 publications

(1 reference statement)

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“…Weiss el al. and Kligman and Weidman (1949) found similar form ations in the fibrinous exudate occurring after inoculation of Cryptococcus neoformans into the anterior cham ber of the rabbit eye.…”

Section: Mycologysupporting

confidence: 54%

Acute Primary Cutaneous Cryptococcosis

Ruiter¹,

Ensink²

1964

Dermatology

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Section: Mycologysupporting

confidence: 54%

Acute Primary Cutaneous Cryptococcosis

Ruiter¹,

Ensink²

1964

Dermatology

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“…Systemic infection in rabbits leads to a higher infection burden in the testis which may reflect a lower temperature in the scrotum (3). In humans, there is a case report of an individual with simultaneous malaria and cryptococcal infection who had clearance of yeast cells in the cerebrospinal fluid during febrile episodes caused by relapsing malaria (13). Heat-sensitive C. neoformans strains have been reported to be rhinotropic, which presumably reflects a tropism of the cooler tissues of the nose (8).…”

mentioning

confidence: 99%

Cryptococcus neoformans var. neoformans (Serotype D) Strains Are More Susceptible to Heat than C. neoformans var. grubii (Serotype A) Strains

2001

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Cryptococcus neoformans var. neoformans (serotype D) and C. neoformans var. grubii (serotype A) differ in geographic prevalence and dermatotropism, with C. neoformans var. neoformans strains being more prevalent among isolates from temperate countries as well as from skin infections. Analysis of 19 strains from each serotype revealed wide variation in thermal susceptibility, with C. neoformans var. neoformans strains being more susceptible, on average, to heat killing. The results suggest a consistent explanation for the geographic differences between serotype A and D strains and for the dermatotropism of serotype D strains.

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“…Previou. experimental inoculations were done by more artificial routes, such as subcutaneous, intraperitoneal, intravenous, or by intranasal instillation (Wade and Stevenson, 1941;Cox and Tolhurst, 1946;Kligman and Weidman, 1949;Hasenclever and Mitchell, 1960;Ritter and Larsh, 1963;Abrahams and Gilleran, 1960).…”

mentioning

confidence: 99%

INFECTION OF WHITE SWISS MICE WITH AIRBORNECRYPTOCOCCUS NEOFORMANS

et al. 1964

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white Swiss male mice were allowed to run 3 days on previously sterilized soil that had been seeded with Cryptococcus neoformans 1 year previously. It was determined that the soil contained an average of 1.6 X 106 viable yeast cells per ml. The mice were observed for 24 weeks, at which time the survivors were necropsied. The total mortality rate during this period was 44%; 67% of the mice had positive cultures, including all who had a fatal infection. Two additional experiments were done with the same strain with the use of aerosols produced by a Henderson apparatus. In experiment 1, 39 mice received 11,000 viable cells each; in experiment 2, 40 mice received 14,622 viable cells. Both groups of mice showed similar mortality rates, with a total of 77% dead after 20 weeks in experiment 1, and 80% in experiment 2. All of the mice in experiment 1 had positive cultures, as did 95% of the mice in experiment 2.

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Experimental Studies on Treatment of Human Torulosis

Cited by 40 publications

References 16 publications

Acute Primary Cutaneous Cryptococcosis

Acute Primary Cutaneous Cryptococcosis

Cryptococcus neoformans var. neoformans (Serotype D) Strains Are More Susceptible to Heat than C. neoformans var. grubii (Serotype A) Strains

INFECTION OF WHITE SWISS MICE WITH AIRBORNECRYPTOCOCCUS NEOFORMANS

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