Acute Primary Cutaneous Cryptococcosis

Primary Cutaneous Cryptococcosis

“…PCC, as well as the systemic form, mostly occurs in patients with compromised host defenses: sarcoidosis [14,23], lymphosar coma [21,25], Hodgkin's lymphoma [22], or corticosteroid therapy [16,18,19,21,[23][24][25]. In some cases, however, no apparent depressed immunity has been found [8-13, 20, 25, 26].…”

“…While some cases were easily cured by simple measures, e.g., incision [8], others with favorable outcome needed specific anticryptococcal therapy with amphotericin B [12, 15, 16, 20. 23, 25, 26], with 5-fluorocytosine [ 10,21 ], or miconazole [9], A fatal outcome, despite appropriate therapy, has been reported [18,24], while fatal sys temic cryptococcosis was noted in other cases some months after healing of the skin lesions [7,25], Amphotericin B is an active substance for intravenous treatment of cryptococcosis, but its use is limited for practical reasons and be cause of side effects and toxicity [27,28], On the other hand. 5-fluorocytosine is given in large doses and induced resistance is report ed frequently [29].…”

Cryptococcosis with Cutaneous Manifestations Treated with 5-Fluorocytosine

“…Infrequently, a chronic infection is established which gives rise to occasional flares of systemic involvement. The second type of disease is associated with Hodgkin's disease, lymphoma [3], leukemia [ 22]: debilitating disease -diabetes mellitus [10]; prolonged use of systemic cor ticosteroids [17]; immunological diseases -sarcoidosis [I], systemic lupus erythematosus, and multiple myeloma [18], In these cases the host defense is minimal and inadequate, and the disease readily spreads to almost all or gans. The case described in this report was probably caused by inhalation of the fungus, and developed systemic involvement without underlying disease.…”

“…Moist, smooth, mucoid, creamcolored colonies are seen 2 days later, the color changing to light brown after about 2 weeks. Also in order to determine the pathogenicity of C. neoformans, 2-to 4-day-old strains are inoculated into mice, especially the white mouse [2,5,6], In sections stained with hematoxylin and eosin, with the PAS reaction or with methenamine silver stain, the cryptococcal cell stains red, but the cryptococcal capsule does not stain; the capsule stains metachromatically purple with methylene blue [12], blue with alcian blue [17], and red with mucicarmine [14] because of the presence of acid mucopolysaccharides [14], When the alcian blue stain and PAS reaction are combined, the yeast cell stains red and the surrounding capsule blue.…”

Torulosis of the Skin

“…Cawley et al [1950J found the incidence of cutaneous manifestations to be 10% and expressed the opinion th at they were usually part of systemic cryptococcosis. On tin; other hand cutaneous torulosis, which remains limited to the skin, is quite rare [Ruiter and Ensink, 1964;Rook and Wood, 1962;McGibbon and Readett, I960].…”