“…While some cases were easily cured by simple measures, e.g., incision [8], others with favorable outcome needed specific anticryptococcal therapy with amphotericin B [12, 15, 16, 20. 23, 25, 26], with 5-fluorocytosine [ 10,21 ], or miconazole [9], A fatal outcome, despite appropriate therapy, has been reported [18,24], while fatal sys temic cryptococcosis was noted in other cases some months after healing of the skin lesions [7,25], Amphotericin B is an active substance for intravenous treatment of cryptococcosis, but its use is limited for practical reasons and be cause of side effects and toxicity [27,28], On the other hand. 5-fluorocytosine is given in large doses and induced resistance is report ed frequently [29].…”