Experimental Studies on the Therapy of Schistosomiasis

Kikuth, Walter; Gönnert, R.

doi:10.1080/00034983.1948.11685374

Cited by 92 publications

(17 citation statements)

References 2 publications

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“…The hepatic shift of the worms, a sensitive criterion for antischistosomal activity (Bang & Hairston, 1946;Kikuth & Goennert, 1948;Standen, 1953;Buttle & Khayyal, 1962), is represented by the percentage of the total number of worms found in the liver. In untreated control hamsters the number of worms in the liver was negligible.…”

Section: Methodsmentioning

confidence: 99%

Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Bueding

Liu

Rogers

1972

British J Pharmacology

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Summary1. No species differences between Schistosoma haematobium and Schistosoma mansoni were detected when the 150 of metrifonate for the acetylcholinesterases (AChE) and the cholinesterases (ChE) of these two trematodes were determined in isolated enzyme preparations or following exposure of the intact worms to this drug in vitro. 2. S. haematabium appeared to be more affected by AChE inhibition because, after administration of metrifonate to hamsters, a hepatic shift of the parasites was observed with a dose of metrifonate (150 mg (0-6 mmol) per kg) which produced no shift of S. mansoni, although AChE inhibition was comparable in both species. 3. Administration of a possible metabolite of metrifonate, dichlorvos, to hamsters resulted in a greater inhibition of AChE and ChE activities of S. haematobium than those of S. mansoni. Furthermore, when schistosomes were incubated with dichlorvos, inhibition of AChE activity of female S. haematobium was significantly greater (P<0 005) than that of both sexes of S. mansoni and of male S. haematobium. 4. The discrepancy between the lack of a significant chemotherapeutic effect of metrifonate in hamsters infected with S. haematobium and the clinical results obtained with this organophosphorus compound in human schistosomiasis haematobium is discussed, and the need to conduct similar studies in primates is pointed out.

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Section: Methodsmentioning

confidence: 99%

Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Bueding

Liu

Rogers

1972

British J Pharmacology

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“… A) Chemical structures of both enantiomers of praziquantel ( 9 ) and their major metabolites 10 . B) Chemical structures of miracil A ( 11 ), oxamniquine ( 13 ), and ( S )‐oxamniquine . C) Oxamniquine ( 13 ) and its mechanism of action .…”

Section: Anthelmintic Drug Therapymentioning

confidence: 99%

Chemotherapy for Fighting Schistosomiasis: Past, Present and Future

et al. 2018

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Chemotherapy based on repeated doses of praziquantel remains the most effective control strategy against schistosomiasis, a neglected tropical disease caused by platyhelminths of the genus Schistosoma spp. Its long-term use, however, raises serious concerns about drug resistance against praziquantel. Therefore, it is generally acknowledged that alternative treatment options are urgently needed. This Review summarizes data on relinquished drugs as well as recent advances in the area of antischistosomal compounds from a medicinal chemistry point of view. Furthermore, insights into the structure-activity relationships of each class of compounds are presented including in vitro and in vivo data, if available. Although many compounds have demonstrated good antischistosomal activity in vitro, they offer little promise to replace praziquantel. Nevertheless, the race to develop novel antischistosomal agents is ongoing.

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“…Posteriormente, os vermes, descasalados e imobilizados, são destruídos, em conseqüên cia de processos degenerativo (4, 9,11,15,16,24,25).…”

Section: Pacientes E Métodosunclassified

Esquistossomose: 1.000 pacientes tratados

Noleto¹,

Neves²,

Magalhães³

et al. 1974

Rev. Soc. Bras. Med. Trop.

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A importância da esquistossomose nas regiões endêmicas do mundo é crescente e preocupa governos e particulares. Além da reconhecida morbidade, que assume as pectos e graus diversos, freqüentemente graves, a expansão da endemia, à custa do próprio homem, confere ao complexo mé-dico-sanitário da parasitose feição mais grave aincla e perspectivas mais sombrias. No Brasil, o fenômeno é patente: migra ções internas aceleradas, em função do sis tema de transporte, hoje ao alcance de to dos, ocorrem como em nenhuma outra época da nossa história.As más condições de vida do povo, em contato com águas poluídas, nas áreas in festadas, somadas aos graves e sérios pro blemas inerentes à profilaxia -vasto pro grama de engenharia sanitária e de re cuperação social do homem -fazem da esquistossomose um tema de interésse pú blico da maior atualidade, que deve figurar,

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Experimental Studies on the Therapy of Schistosomiasis

Cited by 92 publications

References 2 publications

Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes

Chemotherapy for Fighting Schistosomiasis: Past, Present and Future

Esquistossomose: 1.000 pacientes tratados

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