Experimental Salmonella Dublin Infection in Calves

Nazer, A. H. K.; Osborne, A. D.

doi:10.1016/s0007-1935(17)34040-x

Cited by 15 publications

(11 citation statements)

References 12 publications

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“…A large number of researchers have created experimental bovine models of salmonellosis using Salmonella Dublin delivered to calves through an oral route [2,6,15,17,21-23]. Overall, oral infection models that use low pathogen loads produce results more irregular, whereas high pathogen load results in the animals showing typical symptoms, a predictable evolution of the disease, that is, a model where the disease is expressed constantly and evenly.…”

Section: Discussionmentioning

confidence: 99%

Pathogen translocation and histopathological lesions in an experimental model ofSalmonellaDublin infection in calves receiving lactic acid bacteria and lactose supplements

et al. 2012

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The purpose of this study was to evaluate the capacity of a lactic acid bacteria (LAB) inoculum to protect calves with or without lactose supplements against Salmonella Dublin infection by evaluating histopathological lesions and pathogen translocation. Fifteen calves were divided into three groups [control group (C-G), a group inoculated with LAB (LAB-G), and a group inoculated with LAB and given lactose supplements (L-LAB-G)] with five, six, and four animals, respectively. The inoculum, composed of Lactobacillus (L.) casei DSPV 318T, L. salivarius DSPV 315T, and Pediococcus acidilactici DSPV 006T, was administered with milk replacer. The LAB-G and L-LAB-G received a daily dose of 109 CFU/kg body weight of each strain throughout the experiment. Lactose was provided to the L-LAB-G in doses of 100 g/day. Salmonella Dublin (2 × 1010 CFU) was orally administered to all animals on day 11 of the experiment. The microscopic lesion index values in target organs were 83%, 70%, and 64.3% (p < 0.05) for the C-G, LAB-G, and L-LAB-G, respectively. Administration of the probiotic inoculum was not fully effective against infection caused by Salmonella. Although probiotic treatment was unable to delay the arrival of pathogen to target organs, it was evident that the inoculum altered the response of animals against pathogen infection.

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Section: Discussionmentioning

confidence: 99%

Pathogen translocation and histopathological lesions in an experimental model ofSalmonellaDublin infection in calves receiving lactic acid bacteria and lactose supplements

et al. 2012

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“…Calves below the age of 3 months are more susceptible to Salmonella Dublin than older animals leading to more severe clinical signs and more shedding of bacteria in this age group (Nazer & Osborne, 1977;Segall & Lindberg, 1991). Usually, the incidence rate of acute infections is highest in this age-group, but infection (including persistent infection) can occur at any age if the infection dose is sufficiently high.…”

Section: Introductionmentioning

confidence: 99%

A structured approach to control of Salmonella Dublin in 10 Danish dairy herds based on risk scoring and test-and-manage procedures

Nielsen¹,

Nielsen²

2012

Food Research International

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“…Experimental reproduction of salmonellosis in calves is usually achieved by the oral inoculation of large doses of salmonellas which are unlikely to bear relationship to the smaller doses which presumably cause disease under farm conditions. To consistently produce Salmonella dublin infection by the oral route, it has been necessary to use doses of 107-101O organisms (Smith & Jones, 1967;Nazer & Osborne, 1977) and 106_1010 organisms in the case of S. typhimurium (Rankin & Taylor, 1966;DeJong & Ekdahl, 1965;Wray & Sojka, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…In attempts to produce the disease with smaller doses of salmonella, routes other than the oral route have been used. Nazer & Osborne (1977) found that 104 organisms administered into the lumen of the duodenum produced severe disease, whereas larger doses were necessary when the nasal and intratracheal routes were used. Similarly, Forbes, Oakley & MacKenzie (1977) used intravenous inoculation to produce more consistent results because oral inoculation had give variable results.…”

Section: Introductionmentioning

confidence: 99%

Salmonella dublin infection of calves: use of small doses to simulate natural infection on the farm

Wray

Sojka

1981

J. Hyg.

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Small numbers of Salmonella dublin were used to infect calves in an attempt to simulate natural infection on the farm. Twenty calves were exposed to S. dublin by one or more of the following methods: Sucking cows which were excreting S. dublin in their faeces (less than 10(2)-10(5) organisms/g). Housing on S. dublin contaminated bedding. Drinking S. dublin contaminated water (10(2)-10(4) organisms/ml). During this experiment some calves were given therapeutic does of oxytetracycline. After exposure the calves were examined for faecal excretion of S. dublin (in some instances mouth swabs and blood samples were also examined) and for clinical signs of illness. Most of the calves became infected with S. dublin but excretion was usually sporadic and the numbers of salmonellas excreted were small. No clinical signs of salmonellosis were observed by S. dublin was isolated from one calf at post-mortem. Another six calves, dosed orally with either 10(6) or 10(8) S. dublin, showed signs of mild illness and although three calves had diarrhoea excretion of salmonellas was intermittent. S. dublin was isolated from one of these calves at post-mortem.

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Experimental Salmonella Dublin Infection in Calves

Cited by 15 publications

References 12 publications

Pathogen translocation and histopathological lesions in an experimental model ofSalmonellaDublin infection in calves receiving lactic acid bacteria and lactose supplements

Pathogen translocation and histopathological lesions in an experimental model ofSalmonellaDublin infection in calves receiving lactic acid bacteria and lactose supplements

A structured approach to control of Salmonella Dublin in 10 Danish dairy herds based on risk scoring and test-and-manage procedures

Salmonella dublin infection of calves: use of small doses to simulate natural infection on the farm

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