Experimental results of donor site filling for autologous osteochondral mosaicplasty

No effect of subperiosteal growth factor application on periosteal neo-chondrogenesis in osteoperiosteal bone grafts for osteochondral defect repair

“…The only protocol to treat such defects with genuine articular cartilage in one procedure is the transplantation of autologous osteochondral grafts. Applying this technique implies the creation of donor-site defects, which can be responsible for new clinical symptoms, even if the donor-site is assumed to be minor weight bearing [30]. Other techniques include cancellous bone grafts supplemented by either periosteum [12] or autologous bone graft with chondrocyte implantation [31].…”

Press-fit stability of an osteochondral autograft: Influence of different plug length and perfect depth alignment

“…Although short-term and mid-term outcome results are promising (Jakob et al 2002, Bentley et al 2003, Hangody and Fules 2003, Horas et al 2003, there are some problems such as donor site morbidity (Feczko et al 2003, van Susante et al 2003, cartilage integration and survival (Evans et al 2004, Kock et al 2004, Tibesku et al 2004, and cyst formation in the subchondral bone (Pearce et al 2001). Lack of cartilage integration between plug and surrounding cartilage is still an unsolved problem.…”

Clinical experiences with cartilage repair techniques: outcomes, indications, contraindications and rehabilitation

“…In preclinical experimental studies, different biodegradable materials were studied for donor site filling to prevent excessive postoperative bleeding and the quality of repair tissue formation on the surfaces of these plugs were examined. [15] The cylindrical plugs were made of hydroxyapatite, carbon fiber, polyglyconate-B, compressed collagen and polycaprolactones, and were implanted into donor tunnels created in the knees of 50 German Shepherd dogs. All materials effectively decreased postoperative bleeding and arthroscopic and histological evaluations showed a good integration to the surrounding bone, but a limited repair tissue formation with hydroxyapatite, polyglyconate-B, melted polycaprolactone and carbon rods.…”