Experimental radiation synovectomy in rabbit knee with holmium-166 ferric hydroxide macroaggregate

Mãkelä, O.; Penttilä, Pirkko; Kolehmainen, Eila; Sukura, Antti; Sankari, Satu; Tulamo, Riitta‐Mari

doi:10.1016/s0969-8051(02)00317-7

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…Total ablation of synovium in the proximal palmar and plantar joint pouch was not achieved with Ho‐166 FHMA treatment; however, multifocal radiation‐induced necrosis was apparent. Similar partial necrosis of synovium was also reported after Sm‐153 M treatment in horses and Ho‐166 FHMA treatment in rabbits 32,38 . The proliferation of synoviocytes characteristic in control joints was replaced by synovial necrosis in RSYN joints.…”

Section: Discussionsupporting

confidence: 79%

“…The rapid and deep coagulative necrosis probably occurred because of the high dose of Ho‐166 FHMA, resulting in substantial tissue damage, as was observed in rabbit knees 4 days after RSYN with Ho‐166 FHMA 38 . The distribution of histopathologic changes corresponded with the unequal distribution observed by scintigraphy: Changes in the plantar/palmar pouch were profound compared with those in the dorsal recess of the joint capsule.…”

Section: Discussionmentioning

confidence: 61%

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Radiation Synovectomy With Holmium‐166 Ferric Hydroxide Macroaggregate in Equine Metacarpophalangeal and Metatarsophalangeal Joints

et al. 2003

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 61%

Radiation Synovectomy With Holmium‐166 Ferric Hydroxide Macroaggregate in Equine Metacarpophalangeal and Metatarsophalangeal Joints

et al. 2003

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“…40 However, studies showed transient harmful effects of [ 166 Ho]FHMA treatment on immature rabbit cartilage. A higher rate of cartilage matrix synthesis in immature animals compared with adult animals 41 might make the chondrocytes in young cartilage more susceptible to transient irradiation induced derangement of matrix production.…”

Section: Discussionmentioning

confidence: 99%

Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate

Mãkelä

2003

Annals of the Rheumatic Diseases

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Objective: To study the short and long term effects of radiosynovectomy on articular cartilage in growing and mature rabbits. Methods: The articular cartilage of the distal femurs of rabbits was examined four days, two months, and one year after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate ([ 166 Ho]FHMA). Arthritic changes were evaluated from histological sections by conventional and polarised light microscopy, and glycosaminoglycan measurements using safranin O staining, digital densitometry, and uronic acid determination. Proteoglycan synthesis was studied by metabolic [ 35 ]sulphate labelling followed by autoradiography, and electrophoretic analysis of extracted proteoglycans. Northern analyses were performed to determine the mRNA levels of type II collagen, aggrecan, and Sox9 in cartilage samples. Results: Radiosynovectomy had no major effect on the histological appearance of articular cartilage in mature rabbits, whereas more fibrillation was seen in [166 Ho]FHMA radiosynovectomised knee joints of growing rabbits two months after treatment, but not after one year. Radiosynovectomy did not cause changes in the glycosaminoglycan content of cartilage or in the synthesis or chemical structure of proteoglycans. No radiosynovectomy related changes were seen in the mRNA levels of type II collagen, whereas a transient down regulation of aggrecan and Sox9 mRNA levels was seen in young rabbits two months after [166 Ho]FHMA radiosynovectomy. Conclusions: [166 Ho]FHMA radiosynovectomy caused no obvious chondrocyte damage or osteoarthritic changes in mature rabbits, but in growing rabbits some transient radiation induced effects were seen-for example, mild cartilage fibrillation and down regulation of cartilage-specific genes.

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“…In recent years several other radionuclides like Holmium-166, Rhenium-188, Samarium-153, etc. have successfully been introduced [10-18]. …”

Section: Radionuclides Used In Radiosynovectomymentioning

confidence: 99%

Role of radiosynovectomy in the treatment of rheumatoid arthritis and hemophilic arthropathies

Das

2007

Biomed. Imaging Interv. J.

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Radiosynovectomy is a novel method of treatment for several acute and chronic inflammatory joint disorders. A small amount of a beta-emitting radionuclide is injected into the affected joint delivering a radiation dose of 70 to 100 Gy to the synovia. The proliferative tissue is destroyed, secretion of fluid and accumulation of inflammation causing cellular compounds stops and the joint surfaces become fibrosed, providing long term symptom relief. The radionuclides are injected in colloidal form so that they remain in the synovium and are not transported by lymphatic vessels causing radiation exposure to other organs. Complete reduction of knee joint swelling has been seen in above 40% and pain relief in 88% of patients. Wrist, elbow, shoulder, ankle and hip joints showed significant improvement in 50-60% and restoration of normal function and long term pain relief has been achieved in about 70% of small finger joints. In hemophilic arthropathies complete cessation of bleeding in about 60% and improved mobility in 75% of patients has been reported.

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Experimental radiation synovectomy in rabbit knee with holmium-166 ferric hydroxide macroaggregate

Cited by 10 publications

References 31 publications

Radiation Synovectomy With Holmium‐166 Ferric Hydroxide Macroaggregate in Equine Metacarpophalangeal and Metatarsophalangeal Joints

Radiation Synovectomy With Holmium‐166 Ferric Hydroxide Macroaggregate in Equine Metacarpophalangeal and Metatarsophalangeal Joints

Analysis of lapine cartilage matrix after radiosynovectomy with holmium-166 ferric hydroxide macroaggregate

Role of radiosynovectomy in the treatment of rheumatoid arthritis and hemophilic arthropathies

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