Radiation Synovectomy With Holmium‐166 Ferric Hydroxide Macroaggregate in Equine Metacarpophalangeal and Metatarsophalangeal Joints

Mãkelä, O.; Sukura, Antti; Penttilä, Pirkko; Hiltunen, Jukka; Tulamo, Riitta‐Mari

doi:10.1053/jvet.2003.50039

Cited by 9 publications

(1 citation statement)

References 31 publications

(43 reference statements)

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“…165 Ho-labelled FHMA was used as a control. In this study, acute focal radiation necrosis (of the synovium) was observed as well, but in contrast to the study on rabbits, no radiopharmaceutical leakage was found (Makela et al 2003a). The articular cartilage of the horses showed only mild signs of degeneration as a result of this therapy (Makela et al 2004).…”

Section: Radiosynoviorthesiscontrasting

confidence: 70%

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Klaassen¹,

Arntz²,

Arranja

et al. 2019

EJNMMI radiopharm. chem.

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Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.

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Section: Radiosynoviorthesiscontrasting

confidence: 70%