Experimental Production of Bone Marrow Aplasia by Immunological Means

Kumar, Sharad; Saraya, A. K.

doi:10.1159/000206811

Cited by 12 publications

(2 citation statements)

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“…The possibility that autoimmune processes may be responsible for certain human marrow aplasias has been suggested by a variety of animal experiments. Thus, erythropoietin can be inactivated by the administration of specific antisera (Schooley and Garcia, 1962a, b ;Garcia and Schooley, 1963 ;Lange, Gardner, Wright and Gallagher, 1964) and bone marrow proliferation can be inhibited by antisera prepared against erythroblasts (Bjorklund and Hellstrom, 1951;Bracco, Curti and Masera, 1951; Kumar and Saraya, 1962).…”

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Marrow‐Suppressing Factors in the Blood in Pure Red‐Cell Aplasia, Thymoma and Hodgkin's Disease

et al. 1968

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1. A stem cell suppressing factor has been found in the serum of a patient with Hodgkin's disease, a thymic tumour and pure red‐cell aplasia. This factor disppeared when active erythropoiesis returned following radiotherapy to the tumour. 2. The suppressing activity was assayed in mice by measuring the capacity of their bone marrow to restore erythropoiesis in heavily irradiated recipients. 3. Failure to demonstrate a raised erythropoietin level, as well as the finding that IgA and IgM immunoglobulins were reduced, suggested that autoimmune processes might be involved. However, it appeared unlikely that the factor was an autoantibody since suppressing activity was destroyed by storage at −20° C. 4. The sera of nine other patients, one with a thymoma associated with erythroid and megakaryocyte aplasia, three with anterior mediastinal tumours and five with secondary marrow aplasia, were assayed. Three of these showed mild suppressing activity, but this could have been due to non‐specific causes, the nature of which is discussed.

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Marrow‐Suppressing Factors in the Blood in Pure Red‐Cell Aplasia, Thymoma and Hodgkin's Disease

et al. 1968

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“…The myelogenous leukaemia which follows chronic benzol poisoning may be superimposed on aplastic anaemia, or agranulocytosis, the bone marrow being severely hypoplastic or hyperplastic with maturation arrest of granulocytes [4,6,11]. Further, in experimental animals, the production of agranulocytosis following the administration of anti leukocytic scrum is associated in the bone marrow with maturation arrest of successively more and more primitive stages in the chain of granulocytes [9,14] lending the marrow a close resemblance to that of leukaemia, although the peripheral blood shows only a picture of agranulocytosis.…”

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confidence: 99%