Experimental periodontitis in rats potentiates inflammation at a distant site: Role of B1 kinin receptor

Prestes, Ana Paula; Machado, Willian Moreira; Oliveira, Junior Garcia de; Olchanheski, Luiz Ricardo; Santos, Fábio André dos; Alves, Gustavo Ferreira; Prudente, Arthur Silveira; Otuki, Michel Fleith; Paludo, Kátia Sabrina; Fernandes, Daniel

doi:10.1016/j.lfs.2017.12.011

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…The ligature stayed in place during 14 days ( Figure 1 ) until euthanasia. PD induction time was based in inflammatory markers peak associated with ligature protocol [ 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

et al. 2018

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The authors aimed to evaluate the effects of physical exercise on the metabolism and progression of periodontal disease (PD), induced by ligature in diabetic rats induced by high fat diet and streptozotocin (HFD/STZ). Diabetes Mellitus (DM) was induced by four weeks of a hyperlipidic diet associated with a single low-dose of streptozotocin (35 mg/kg/animal). The exercise groups swam for 60 min/day for eight weeks (five times/week). In the last two weeks of exercise, a ligature was placed around the right and left mandibular first molars. The authors determined alveolar bone loss by morphometry. Blood biochemical profile and serum levels of IL-10 and TNF-α were evaluated by colorimetric and enzyme-linked immunosorbent assays (ELISA), respectively. The diabetic animals subjected to exercise showed decreased alveolar bone loss, lower glycemia, triacylglycerols and glycosylated hemoglobin levels than the controls. Total cholesterol and its fractions (High density lipoprotein—HDL-c, Low density lipoprotein—LDL-c and Very low density lipoprotein—VLDL-c) remained similar among the groups. Animals with PD showed higher levels of TNF-α and lower levels of IL-10, when compared to animals without PD. In diabetic animals with PD, physical exercise decreased TNF-α levels and increased IL-10 levels as well as the IL10/TNF-α ratio. In conclusion, eight weeks of physical exercise improved glycemic control and systemic inflammatory profile, and attenuated alveolar bone loss in rats with DM and PD.

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“…The ligature stayed in place during 14 days ( Figure 1 ) until euthanasia. PD induction time was based in inflammatory markers peak associated with ligature protocol [ 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

et al. 2018

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“…Histopathological changes in synoviocytes were examined under a microscope. Participation of the cholinergic organism in the effects of CTX was examined by after treatment of animals with the α7 nicotinic receptor (α7-nAChR) antagonist methyllycaconitine (MLA) [72].…”

Section: Fruends Complete Adjuvant Induced Arthritismentioning

confidence: 99%

Recent and advanced animal models used in the Screening of analgesics and anti-inflammatory activity

Krishna¹,

Maurya²

2018

IJPBR

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Non-Steroidal anti-inflammatory drugs (NSAIDs) are consisting of three major anti-pyretic, anti-inflammatory and anti-analgesics properties. They have reduced the sensation of pain, body temperature, and inflammation. It is also used for the treatment of the long-term health problems like arthritis (rheumatoid arthritis, osteoarthritis, and lupus). NSAIDs highly protect the lining of the stomach and intestines from the damaging effects of acid promote blood clotting by activating blood platelets, and promote normal function of the kidney. Incompatible with the action of NSAIDs many different types of drugs and plant use for the treatment of the analgesic, inflammation and pyretic activity. Diclofenac inhibit the cyclooxygenase (COX-2) enzyme with the greater potency that it (COX-1). NSAIDs are generally used in the management of pain because of the integrated role of the COX pathway that is recognition of pyretic, inflammation and analgesic. Introduction to painful procedures and/or stressors during the early neonatal period can reprogram the underlying neurocircuitry involved in nociception and neuropathic pain perception. The reprogramming of these systems can result in an enduring elevation in sympathy towards mechanical and thermal stimuli. During adolescence, hind paw mechanical removal thresholds were evaluated using an electronic von Frey Anesthesiometer. Animals challenged neonatally with LPS (nLPS) had increased pain sensitivity on this measure which was related with decreased Oprm1 expression in the prefrontal cortex (PFC) and periaqueductal gray (PAG) of both male and female rats. There was no effect of inflammatory treatment on either anxiety or depressive-like behavior suggesting that affective functioning did not account for differences in mechanical pain sensitivity.

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Effect of caloric restriction on alveolar bone loss in rats

et al. 2021

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Experimental periodontitis in rats potentiates inflammation at a distant site: Role of B1 kinin receptor

Cited by 3 publications

References 45 publications

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

Recent and advanced animal models used in the Screening of analgesics and anti-inflammatory activity

Effect of caloric restriction on alveolar bone loss in rats

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