Experimental parathyroid transplantation: human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody

Niimi, Masanori; Takashina, Motoi; Takami, Hiroshi; Shirasugi, Nozomu; Hamano, Kimikazu; Esato, Kensuke; Matsumoto, Kazuaki; Ikeda, Yoshifumi; Shatari, Tomoo; Kodaira, Susumu; Kameyama, Kaori

doi:10.1016/s0753-3322(00)80018-9

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…12 In a xenotransplantation model, human parathyroid tissue was transplanted into mice, followed by anti-CD4 monoclonal antibody therapy. 13 Human parathyroid hormone could be found over a time period of 30 days in recipient mice. In contrast to these studies, graft pretreatment was not performed in our experiments, as the impact of donor-derived MHC class II positive ''passenger leukocytes'' on the mechanisms of nonvascularized graft rejection is not yet verified.…”

Section: Discussionmentioning

confidence: 99%

Short‐term immunosuppression after rat parathyroid allotransplantation

et al. 2003

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The aim of this study was to evaluate whether short-term postoperative immunosuppression is able to sufficiently prolong graft survival after experimental allogeneic parathyroid transplantation. Heterotopic parathyroid transplantation was performed in 6 groups: 1) syngeneic control Lewis (LEW) to LEW; 2) allogeneic control Wistar-Furth (WF) to LEW; 3-5) WF to LEW plus short-term immunosuppression, postoperative days 1-13 (cyclosporine 5/10/20 mg/kg); and 6) WF to LEW plus 10 mg/kg CyA from preoperative day 7 to postoperative day 7. Graft function was examined up to 60 days; histological and immunohistological examination was performed on all grafts with impaired function. Graft function after syngeneic transplantation was indefinite, while recipients of allogeneic grafts turned hypocalcemic after 13 +/- 2 days. With immunosuppression, graft function was 21 +/- 2 days (groups 5 and 6) and 28 +/- 3 days (groups 3 and 4). Histologically, a cellular infiltrate responsible for graft destruction was found. The results show that indefinite parathyroid allograft survival cannot be achieved by short-term immunosuppression alone. Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined.

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Section: Discussionmentioning

confidence: 99%

Short‐term immunosuppression after rat parathyroid allotransplantation

et al. 2003

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“…These included the kidney capsule, the anterior chamber of the eye, and the cerebral ventricle and also produced varying results (19 -21). Other theories suggested that short-term immunosuppression (cyclosporine A), pretransplantation treatment of grafts by culturing them in a 5% CO 2 atmosphere, or x-ray irradiation may promote long-term graft survival (7,22,23). During the early phases of the study, we considered oral administration of cyclosporine in the first 3 days posttransplantation.…”

Section: Discussionmentioning

confidence: 99%

Allotransplantation of Cultured Parathyroid Progenitor Cells Without Immunosuppression: Clinical Results

et al. 2007

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“…However, the authors used a rather weak rat strain combination, as attested to by the relatively long retention of graft function in the untreated allogeneic control group [27]. In another study employing a xenotransplantation model, human parathyroid tissue was transplanted into mice treated with an anti-CD4 monoclonal antibody [28]. Human parathyroid hormone was found in the recipient mice over a period of 30 days after transplantation.…”

Section: Discussionmentioning

confidence: 99%