Experimental optimization of Lornoxicam liposomes for sustained topical delivery

Joseph, Joshny; N, Vedha Hari B; D, Ramya Devi

doi:10.1016/j.ejps.2017.10.032

Cited by 53 publications

(16 citation statements)

References 33 publications

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“…Particle morphology of the targeting liposomes was determined by a transmission electron microscopy (TEM, FEI Co., PDX, USA) and an atomic force microscopy (AFM, NSK Ltd., Tokyo, Japan). The particle diameter and zeta potential of the targeting liposomes were measured by a Nano Series Zen 4003 Zetasizer (Malvern Instruments Ltd., Malvern, UK) and the polydispersity index (PDI) was used to measure the size distribution [22]. The concentration of vinorelbine in liposomal formulations was analyzed by a high-performance liquid chromatography (HPLC) equipped with a UV detector (Agilent Technologies Inc., Cotati, CA).…”

Section: Characterization Of the Liposomesmentioning

confidence: 99%

Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma

Xiao

Cheng

Xie

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Glioma is the most common primary malignant brain tumor with a poor prognosis. The application of chemotherapeutic drugs is limited due to the existence of blood-brain barrier and serious side effects. Liposomes have been proven to be a stable and useful drug delivery system for tumors. In this paper, WGA (wheat germ agglutinin) modified vinorelbine cationic liposomes had been successfully constructed for treating glioma. In the liposomes, WGA was modified on the liposomal surface for crossing the blood-brain barrier and increasing the targeting effects, 3-(N-(N 0 , N 0-dimethylaminoethane) carbamoyl) cholesterol (DC-Chol) was used as cationic material and vinorelbine was encapsulated in the aqueous core of liposomes to inhibit tumor metastasis and kill tumor cells. Studies were performed on C6 cells in vitro and were verified in brain glioma-bearing mice in vivo. Results in vitro demonstrated that the targeting liposomes could induce C6 cells apoptosis, promote drugs across the blood-brain barrier, inhibit the metastasis of tumor cells and increase targeting effects to tumor cells. Meanwhile, action mechanism studies showed that the targeting liposomes could down-regulate PI3K, MMP-2, MMP-9 and FAK to inhibit tumor metastasis. Results in vivo exhibited that the targeting liposomes displayed an obvious antitumor efficacy by accumulating selectively in tumor site and exhibited low toxicity to blood system and major organs. Hence, WGA modified vinorelbine cationic liposomes might provide a safe and efficient therapy strategy for glioma.

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Section: Characterization Of the Liposomesmentioning

confidence: 99%

Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma

Xiao

Cheng

Xie

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…It has potential gastrointestinal, liver, cardiac and renal toxicities. 9 Many approaches were previously used to overcome the side effects of LX such as liposomes, 9 proniosomal gel, 10 and niosomes. 11 Transdermal delivery system provides an approach to avoid the side effects of NSAIDs and extend duration of action.…”

Section: Introductionmentioning

confidence: 99%

“…The FTIR spectra of LX, SDC, SPC and the lyophilized optimized bilosomal formula are shown in Figure 5. 9 The characteristic peaks SDC are shown at 2937 (aliphatic C-H), 1559 cm −1 (carbonyl group). 62 The characteristic peaks SPC are shown at 1069 (-C-O-), 1465 (-C=C-), 1740 (-C=O-), 2924 cm −1 (-C-H-).…”

mentioning

confidence: 98%

<p>Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation</p>

Ahmed¹,

Kassem²,

Sayed³

2020

IJN

107

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“…Peaks appearing at 1143–1380 cm −1 were related to stretching vibration of O S O. Peak appearing at 788 cm −1 was designated as C—Cl stretch in the aliphatic chloro group of the drug ( Joseph, 2018 ). Peak corresponding to C—H stretching vibration of aromatic ring was also evident at 3064 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

“…However, when lornoxicam is converted into a suitable dosage form with improved aqueous solubility for effective dissolution, it shows a rapid onset of action ( Tawfeek et al, 2014 , Fule et al, 2014 ). Nevertheless, its short half-life of 3–4 h often necessitates its frequent oral dosing with an increased risk of side effects such as gastrointestinal disorders, skin irritation, headaches, nausea and in severe cases it can lead to renal damage ( Joseph, 2018 ). Hence, to overcome these side effects, an extended release topical lornoxicam product would be necessary.…”

Section: Introductionmentioning

confidence: 99%

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

He¹,

Majid

Maqbool

et al. 2020

Saudi Pharmaceutical Journal

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Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The microsponges were formulated using quasi emulsion-solvent diffusion method employing four different surfactant systems, namely polyvinyl alcohol (PVA), Tween80, Gelucire 48/16 and Gelucire 50/13. All the lornoxicam loaded microsponge formulations were extensively characterized with a variety of analytical tools. The optimized microsponge formulation was then converted into gel formulation. The lornoxicam loaded microsponge gel formulation had adequate viscosity and sufficient pharmaceutical properties as confirmed by the texture analysis and the drug release followed Super case II transport. It is noteworthy that we described the preparation of a new cellulosic polymers based microsponge system for delivery of lornoxicam to provide quick as well as lasting (sustained) anti-inflammatory effects in rats using carrageenan induced rat paw edema model. We were able to demonstrate a 72% reduction in inflammation within 4 h using the optimize transdermal gel formulation utilizing Transcutol P as permeation enhancer and with the aid of skin micro-piercing by microneedles, hence, demonstrating the potential of this microsponge gel formulation in arthritis management.

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Experimental optimization of Lornoxicam liposomes for sustained topical delivery

Cited by 53 publications

References 33 publications

Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma

Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma

<p>Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation</p>

Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

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