Experimental Myocardial Infarction

Lactate Dehydrogenases: Structure and Function

“…In an embryonic heart there is a net production of lactate (202,203). Lactate production by heart tissue also occurs in patients with coronary heart disease, and in experimental myocardial infarction ( 204,205). Under conditions where the oxygen supply to the heart tissue is diminished, one might expect a tendency for accumulation of DPNH.…”

Reparative Processes in Heart Muscle Following Myocardial Infarction

“…Each of these stages is ac companied by definite biochemical processes. In the first stage, blood flows into the gap created by the wound, clots, and unites the edges of 1 Supported by grants from the American Medical Association, Council for Tobacco Research and Hoover Foundation, Los Angeles, Calif. the wound. In the myocardium, a frank hemorrhage is not seen, al though one of the first findings in the infarcled area consists in hemor rhagic foci [1].…”

“…In the first stage, blood flows into the gap created by the wound, clots, and unites the edges of 1 Supported by grants from the American Medical Association, Council for Tobacco Research and Hoover Foundation, Los Angeles, Calif. the wound. In the myocardium, a frank hemorrhage is not seen, al though one of the first findings in the infarcled area consists in hemor rhagic foci [1]. In the myocardium the first pathological event is cell necrosis [1], During the second stage, various kinds of white blood cells migrate into the wound and remove and break down vellular debris and other foreign material.…”

“…In the myocardium, a frank hemorrhage is not seen, al though one of the first findings in the infarcled area consists in hemor rhagic foci [1]. In the myocardium the first pathological event is cell necrosis [1], During the second stage, various kinds of white blood cells migrate into the wound and remove and break down vellular debris and other foreign material. In the third stage, fibroblasts enter the wound and build the scar tissue by manufacturing collagen fibers and other pro teins.…”

Biochemical Changes of the Rat Myocardium Induced by Isoproterenol

“…An expansion of the extracellular space is not specifically connected w-ith infarction; it also occurs in hypertrophic rabbit hearts (10). I t is interesting t o remember that an Whereas several obsea-ations were made on chemical changes occ~arring in myocardial infarction a frer ~oronarj7 ligation (8, 9,12,131, similar determinations were not carried out in isoproterenol cardiopathy. Present investigation was undertaken to look into the chemical conapositlon of the hearts of rats following isoproterenol treatment.…”