2018
DOI: 10.1097/j.pain.0000000000001351
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Experimental muscle hyperalgesia modulates sensorimotor cortical excitability, which is partially altered by unaccustomed exercise

Abstract: Impaired corticomotor function is reported in patients with lateral epicondylalgia, but the causal link to pain or musculotendinous overloading is unclear. In this study, sensorimotor cortical changes were investigated using a model of persistent pain combined with an overloading condition. In 24 healthy subjects, the effect of nerve growth factor (NGF)-induced pain, combined with delayed-onset muscle soreness (DOMS), was examined on pain perception, pressure pain sensitivity, maximal force, and sensorimotor c… Show more

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Cited by 29 publications
(41 citation statements)
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References 64 publications
(83 reference statements)
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“…Particularly, the increased corticomotor excitability is not generally evident after the first injection of NGF in those studies. This complex dynamic relationship between corticomotor facilitation and inhibition has been demonstrated (De Martino, Zandalasini, et al, ) and it is also presupposed by the most recent models concerning the relationship between pain and motor function (Hodges & Smeets, ; Hodges & Tucker, ), (c) the functional and motor control differences between the upper limb muscles and the jaw muscles. The masseter is a jaw closing muscle that is mostly related with the rhythmic movements of mastication and, therefore, its motor output is subjected to complex modulatory controls (Lund, ).…”
Section: Discussionmentioning
confidence: 67%
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“…Particularly, the increased corticomotor excitability is not generally evident after the first injection of NGF in those studies. This complex dynamic relationship between corticomotor facilitation and inhibition has been demonstrated (De Martino, Zandalasini, et al, ) and it is also presupposed by the most recent models concerning the relationship between pain and motor function (Hodges & Smeets, ; Hodges & Tucker, ), (c) the functional and motor control differences between the upper limb muscles and the jaw muscles. The masseter is a jaw closing muscle that is mostly related with the rhythmic movements of mastication and, therefore, its motor output is subjected to complex modulatory controls (Lund, ).…”
Section: Discussionmentioning
confidence: 67%
“…Overall, our findings that suggest decreased corticomotor excitability direct oppose the vicious cycle theory (Travell et al, ). Nonetheless, recent studies have presented the opposite effect for the spinal innervation, i.e., increased corticomotor excitability following repeated injections of NFG into the extensor carpi radialis brevis (ECRB), which is likely explained as a motor learning effect that results from the search for a new moment strategy in the affected limb (De Martino, Seminowicz, Schabrun, Petrini, & Graven‐Nielsen, ; De Martino, Zandalasini, Schabrun, Petrini, & Graven‐Nielsen, ; Schabrun, Christensen, Mrachacz‐Kersting, & Graven‐Nielsen, ). There are some important methodological differences that could account for these contradictory findings, besides the need of the above‐mentioned pre‐activation level: (a) the tonic muscle contractions could have facilitated nociceptive inputs in the NGF injected masseter.…”
Section: Discussionmentioning
confidence: 99%
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“…Using a TMS intensity of 120% rMT, the motor cortical map was established based on MEPs evoked every 6 s with a total of 5 stimuli at each site on the stimulation grid De Martino et al, 2018). All grid sites were pseudo randomly stimulated from the hotspot until no MEP was recorded (defined as <50 µV peak-to-peak amplitude) in all five stimuli at all border sites .…”
Section: Motor Evoked Potentials and Motor Mapmentioning
confidence: 99%
“…Grip force strength. Grip force strength can be measured as a nonevoked quantitative measure and has been used to assess sustained muscle pain in experimental muscle hyperalgesia in healthy subjects induced by nerve growth factor 180 ; however, weak muscle performance, myalgia, and motivation of the patient may influence outcomes. Table 2 presents the pain panel's recommendations for prioritization, recognizing that the gold standard for pain assessment is patient report.…”
Section: Measures Of Underlying Pain Mechanisms: Pain/ Vaso-occlusivementioning
confidence: 99%