Experimental monkey hosts for human plasmodia

Adaptation of a Thai Multidrug-Resistant C2A Clone of Plasmodium falciparum to Aotus Monkeys and Its Preliminary in vivo Antimalarial Drug Efficacy-Resistance Profile

“…6 For more than 40 years, the Panamanian Aotus ( Aotus lemurinus. lemurinus ) has been used to adapt new strains of malaria [7][8][9] study its biology, [10][11][12] pathogenesis of its infection, [13][14][15] and to test the efficacy and pharmacokinetics of antimalarial compounds [16][17][18][19][20][21][22][23][24][25][26][27] against these new strains. More recently, this model has also been used to test the efficacy and immunogenicity of antimalarial vaccines through the use of repeated challenge, 28 plasmid DNA vaccines, [29][30][31][32] temperature-sensitive mutants, 33 synthetic peptides, 34 recombinant proteins, [35][36][37] and even to test the immunogenicity of hepatitis B DNA vaccines.…”

The Infection Rates of Trypanosomes in Squirrel Monkeys at Two Sites in the Brazilian Amazon

“…Saimiri, as well as Aotus monkeys, are successful experimental models (WHO 1988) for human malaria parasites P. falciparum and P. vivax (Deane et al 1966, Deane 1967, Geiman & Meagher 1967, Young & Rossan 1969, Young et al 1971, 1975, Rossan et al 1972a, b, Schmidt 1978, Gysin et al 1980, Campbell et al 1980, Gysin & Nussenzweig 1982, Gysin & Fandeur 1983, Collins et al 1983, Gysin 1991. Squirrel monkeys have also been used in aerospace (Beischer 1968) and pharmacological (Hanson 1968) research.…”

Hematologic Values of Normal Bolivian Squirrel Monkeys (Saimiri sciureus): a Comparison between Wild-Caught and Laboratory-Bred Male Animals

“…The higher eosinophil counts observed by Garcia and Hunt [1966] may be due to stim ulation by parasitic antigens as observed in human beings resident in tropical regions [Greenwood and Little, 1981], Our observations within the context of published data might highlight the inherent, environmentally-induced effects on blood values analogous to those observed on hu man immunoglobulin levels [Greenwood and Little, 1981]. Therefore, it is imperative that squirrel monkeys, such as those used in malaria research [Young et al, 1975;Collins et al, 1978;Gysin et al, 1980;Dubois et al, 1984] where immunohematologic parame ters are of considerable importance, should be of the same origin and preferably bred and raised under the same conditions either in the wild or in the laboratory. Clearly laboratory-bred animals offer numerous advantages over wild-caught animals, thus breeding pro grams should be encouraged as suggested by other investigators [Long and Cooper, 1968;Kaplan, 1977].…”

“…sympathomimetic agents, and in aerospace medical research [Beischer, 1968]. Squirrel monkeys have been found suitable for use in experimental malariology [Rossan et al, 1972a, b;Young et al, 1975;Collins et al, 1978;Gysin et al, 1980] with recent stud ies pertaining to the induction of protective immunity to Plasmodium falciparum [Du bois et al, 1984]. Most of these studies have involved wild-caught monkeys.…”