Experimental Models of Acute Pancreatitis

Acute Interstitial Pancreatitis in Rats Induced by Dibutyltin Dichloride (DBTC)

“…In the further course of DBTC-induced pancreatitis, we observed time-dependent fibrosis in the pancreas (23). This result differs from other experimental pancreatitis models (24,25), because extensive infiltration by mononuclear cells appeared in fibrotic areas without pancreatic atrophy or lipomatosis (Table 1). Simple ligation of the pancreatic duct produces atrophy of the pancreatic acinar tissue without pancreatitis (26,27).…”

“…The different experimental models of acute pancreatitis (25) are useful for testing therapy concepts as well as elucidating the pathogenesis of human pancreatitis. No relevant model could be established for human chronic pancreatitis.…”

Basic Experimental Pancreatitis Models for Beginners

“…Acute pancreatitis is a multi-etiology disease with controversial physiopathology. Thus, it has an unpredictable course without a targeted treatment [1] which results in high morbidity and mortality.…”