Experimental Model for the Study of Osteogenesis and Remodeling

Najjar, Talib A.; Kahn, David

doi:10.1177/00220345710500042801

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…According to the literature, it was emphasized that the bone defect that should be created in experimental animal models should not be less than the critical size, that the defect should include both cortical and cancellous bone, and that the defect areas should be kept at an appropriate distance so that the biomaterials used do not affect each other. In the study, it was observed that the size of the critical defect in the tibia bone was determined as '>5 mm′ in the sample studies [ [28] , [29] , [30] ]. In line with this information, standardized defects of 6 mm diameter and 5 mm depth were created in the right and left tibia bones of each animal.…”

Section: Discussionmentioning

confidence: 99%

In vivo comparison of customized zirconia barriers in guided bone regeneration: An experimental study

Tuncludemir,

Cinar,

Avcı Kupeli

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

In vivo comparison of customized zirconia barriers in guided bone regeneration: An experimental study

Tuncludemir,

Cinar,

Avcı Kupeli

et al. 2024

Heliyon

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“…The differences in the amount of healing and so, the CSD determination could be attributed to several factors, including the species and strains of the animals utilized along with the anatomic location, 28 defect size, 29 periosteum intactness, 30 dura matter, 31 and animal age 18 . In this study, all factors have been standardized to highlight the effect of age.…”

Section: Discussionmentioning

confidence: 99%

Influence of Age on Calvarial Critical Size Defect Dimensions: A Radiographic and Histological Study

Hudieb

Haddad

Bakeer

et al. 2021

Journal of Craniofacial Surgery

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Calvarial critical-size defect has been used to assess techniques and materials in the bone regeneration field. Previous studies utilized young adult rats with 3 months of age, which might not reflect the geriatric conditions. This study aimed to assess the dimensions of the calvarial critical-size defect in aged rats. Seventy-two rats in a randomized block design were allocated into a control young adult (11–12 weeks), and a test old group (22–24 months). Both groups were divided according to bone defect's size: 3 mm, 5 mm, and 7 mm defects, which were surgically created and followed for 4 and 8 weeks. Radiographic and histologic analyses were performed. Based on the results, additional groups with 4 mm defect size were added following the same protocols. Young groups yielded higher bone volumes, defect closure percentages, and density of newly formed bone. Closure of cranial defects was only observed in 3 mm defects in both age groups after 8 weeks; however, the 4 mm defect group demonstrated bony bridging after 8 weeks in young but not old rats. Results confirmed that 5-mm defect is considered a critical size for calvarial bone defects in young adult rats; however, 4 mm defect might be considered critical size for the aged rats after 8 weeks.

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“…(Peacock and Winkle, 1970). Ορισμένοι συγγραφείς παρόλαυτά υποστηρίζουν ,ότι αποδό μηση οστού είναι δυνατόν να γίνει και χωρίς την παρουσία κυττά-, ρων που μορφολογικά να αναγνωρίζονται σαν οστεοκλάστες (Belanger and Vincent 1963, Henrikson 1968, Najjar and Kahn 1971.…”

Section: οιunclassified

Πειραματικη Μελετη Αναγεννησης Μετα Απο Χειρουργικη Εκτομη Της Γωνιαιας Αποφυσης Της Κατω Γναθου Στο Κουνελι

Αινατζογλου¹

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ΣΤΗΝ ΠΕΙΡΑΜΑΤΙΚΗ ΑΥΤΗ ΜΕΛΕΤΗ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ 19 ΑΝΑΠΤΥΣΣΟΜΕΝΑ ΚΑΙ 4 ΕΝΗΛΙΚΑ ΚΟΥΝΕΛΙΑ ΤΗΣ ΦΥΛΗΣ ΤΗΣ ΝΕΑΣ ΖΗΛΑΝΔΙΑΣ. ΕΞΗ ΑΠΟ ΤΑ ΑΝΑΠΤΥΣΣΟΜΕΝΑ ΚΑΙ ΔΥΟ ΑΠΟ ΤΑ ΕΝΗΛΙΚΑ ΠΕΙΡΑΜΑΤΟΖΩΑ ΥΠΟΒΛΗΘΗΚΑΝ ΣΕ ΧΕΙΡΟΥΡΓΙΚΗ ΕΚΤΟΜΗ ΤΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ ΚΑΙ ΑΛΛΑ ΤΟΣΑ ΣΕ ΕΠΙΠΛΕΟΝ ΑΠΟΚΑΤΑΣΤΑΣΗ ΤΗΣ ΠΡΟΕΓΧΕΙΡΗΤΙΚΗΣ ΘΕΣΗΣ ΤΩΝ ΜΑΛΑΚΩΝ ΜΟΡΙΩΝ ΤΗΣ ΠΕΡΙΟΧΗΣ ΜΕ ΤΗΝ ΑΚΡΙΒΗ ΤΟΠΟΘΕΤΗΣΗ ΕΝΟΣ ΝΑΡΘΗΚΑ ΑΠΟ ΑΝΟΞΕΙΔΩΤΟ ΣΥΡΜΑ. ΜΕΛΕΤΗΘΗΚΑΝ ΜΕ ΤΟΝ ΤΡΟΠΟ ΑΥΤΟ Η ΜΟΡΦΟΛΟΓΙΚΗ ΕΞΕΛΙΞΗ ΤΗΣ ΑΝΑΓΕΝΝΗΜΕΝΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ ΜΕΧΡΙ ΤΗΝ ΕΝΗΛΙΚΙΩΣΗ ΤΩΝ ΠΕΙΡΑΜΑΤΟΖΩΩΝ, Η ΠΙΘΑΝΗ ΣΗΜΑΣΙΑ ΤΗΣ ΗΛΙΚΙΑΣ ΣΤΟ ΦΑΙΝΟΜΕΝΟ ΤΗΣ ΟΣΤΙΚΗΣ ΑΝΑΓΕΝΝΗΣΗΣ ΚΑΘΩΣ ΚΑΙ Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΕΠΕΜΒΑΣΗΣ ΣΤΗΝ ΑΥΞΗΣΗ ΤΟΥ ΟΛΟΥ ΟΣΤΟΥ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ. ΑΝΑΓΕΝΝΗΣΗ ΤΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ ΠΑΡΑΤΗΡΗΘΗΚΕ Σ' ΟΛΑ ΤΑ ΑΝΑΠΤΥΣΣΟΜΕΝΑ ΚΟΥΝΕΛΙΑ ΠΟΥ ΕΙΧΑΝ ΟΜΑΛΗ ΜΕΤΕΓΧΕΙΡΗΤΙΚΗΠΟΡΕΙΑ ΚΑΙ ΣΕ ΚΑΝΕΝΑ ΑΠΟ ΤΑ ΕΝΗΛΙΚΑ ΚΑΤΑ ΤΗΝ 150Η ΗΜΕΡΑ ΤΗΣ ΖΩΗΣ Η ΑΣΥΜΜΕΤΡΙΑ ΜΕΤΑΞΥ ΠΕΙΡΑΜΑΤΙΚΗΣ ΚΑΙ ΑΘΙΚΤΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ ΗΤΑΝ ΠΕΡΙΠΟΥ Η ΙΔΙΑ ΣΕ ΟΛΑ ΤΑΧΕΙΡΟΥΡΓΗΜΕΝΑ ΠΕΙΡΑΜΑΤΟΖΩΑ. Η ΕΞΕΛΙΞΗ ΤΗΣ ΑΝΑΓΕΝΝΗΜΕΝΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ, ΜΕΤΑ ΤΟ ΑΡΧΙΚΟ ΣΤΑΔΙΟ ΤΗΣ ΟΣΤΙΚΗΣ ΑΝΑΓΕΝΝΗΣΗΣ, ΦΑΙΝΕΤΑΙ ΟΤΙ ΒΡΙΣΚΟΤΑΝ ΣΕ ΣΤΕΝΗ ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΩΝ ΜΥΩΝ ΤΗΣ ΠΕΡΙΟΧΗΣ. Η ΑΦΑΙΡΕΣΗ ΤΗΣ ΓΩΝΙΑΙΑΣ ΑΠΟΦΥΣΗΣ ΔΕΝ ΕΙΧΕ ΚΑΜΜΙΑ ΕΠΙΔΡΑΣΗ ΣΤΗΝ ΑΥΞΗΣΗ ΤΟΥ ΟΣΤΟΥ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ. ΤΑ ΕΥΡΗΜΑΤΑ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΥΤΗΣ ΕΙΝΑΙ ΔΥΝΑΤΟΝ ΝΑ ΕΡΜΗΝΕΥΤΟΥΝ ΜΕ ΤΗ ΘΕΩΡΙΑ ΤΗΣ ΛΕΙΤΟΥΡΓΙΚΗΣ ΜΗΤΡΑΣ .

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Experimental Model for the Study of Osteogenesis and Remodeling

Cited by 15 publications

References 5 publications

In vivo comparison of customized zirconia barriers in guided bone regeneration: An experimental study

In vivo comparison of customized zirconia barriers in guided bone regeneration: An experimental study

Influence of Age on Calvarial Critical Size Defect Dimensions: A Radiographic and Histological Study

Πειραματικη Μελετη Αναγεννησης Μετα Απο Χειρουργικη Εκτομη Της Γωνιαιας Αποφυσης Της Κατω Γναθου Στο Κουνελι

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