Experimental Knee Pain Reduces Muscle Strength

Henriksen, Marius; Rosager, Sara; Aaboe, J.; Graven‐Nielsen, Thomas; Bliddal, Henning

doi:10.1016/j.jpain.2010.10.004

Cited by 131 publications

(135 citation statements)

References 36 publications

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“…It has recently been demonstrated that patients with knee OA who have quadriceps activation failure acquire greater volitional quadriceps activation and muscle strength gain from an intervention aimed at blocking pain sensation centrally in combination with exercise (49). Second, the average pain intensity was 16.2 mm, which is lower than that reported in previous studies (25)(26)(27)36). The time course of experimental IPFP pain shows that maximum pain intensity is reached within 5 minutes, and then gradually declines over the following 10 -12 minutes (23).…”

Section: Discussionmentioning

confidence: 64%

“…Second, the "pain adaptation" theory hypothesizes that pain inhibits agonistic muscles and facilitates antagonistic muscle activity (35). Excitation of group III and IV afferents can reduce muscle force, electromyographic activity, and discharge rate of some motor units (14,17,25,27,36), and reduce quadriceps activation. Our data do not support this hypothesis, as uniform inhibition of the quadriceps in the pain group would be expected to reduce the training volume and a parallel lower strength gain over time compared to the control group, but no differences in training volume and a larger strength gain were found in the pain group.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical knee joint pain arises from several structures, including the IPFP, and is a significant source of pain in patients with knee OA (47,48). Furthermore, experimental pain from the IPFP has been shown to change motor functions similar to those identified in knee pathology (22,23,25,26). However, experimental pain does not replicate the long-term aspects of clinical pain, including the psychosocial features.…”

Section: Discussionmentioning

confidence: 99%

“…Maximal isokinetic torque produced in knee extension and flexion with the subject's right knee was recorded in a sitting position (Biodex System 3, pro set; Biodex Medical Systems). The method has been described elsewhere (25).…”

Section: Significance and Innovationsmentioning

confidence: 99%

“…Experimental knee pain models make it possible to test the isolated effects of pain on motor functions in healthy volunteers without the influence of confounding disease-related factors (24). It has recently been demonstrated that experimental knee joint pain significantly reduces knee muscle strength (25) as well as causing gait changes comparable to changes seen in knee OA (26). Likewise, experimental knee joint pain induces changes in motor control of the quadriceps (22) and alters the motor unit discharge rate and recruitment strategies (27).…”

Section: Introductionmentioning

confidence: 99%

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Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: A randomized controlled trial

Sørensen¹,

Langberg²,

Hodges³

et al. 2011

Arthritis Care & Research

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Objective. Knee joint pain and reduced quadriceps strength are cardinal symptoms in many knee pathologies. In people with painful knee pathologies, quadriceps exercise reduces pain, improves physical function, and increases muscle strength. A general assumption is that pain compromises muscle function and thus may prevent effective rehabilitation. This study evaluated the effects of experimental knee joint pain during quadriceps strength training on muscle strength gain in healthy individuals. Methods. Twenty-seven healthy untrained volunteers participated in a randomized controlled trial of quadriceps strengthening (3 times per week for 8 weeks). Participants were randomized to perform resistance training either during pain induced by injections of painful hypertonic saline (pain group, n ‫؍‬ 13) or during a nonpainful control condition with injection of isotonic saline (control group, n ‫؍‬ 14) into the infrapatellar fat pad. The primary outcome measure was change in maximal isokinetic muscle strength in knee extension/flexion (60, 120, and 180 degrees/second). Results. The group who exercised with pain had a significantly larger improvement in isokinetic muscle strength at all angular velocities of knee extension compared to the control group. In knee flexion there were improvements in isokinetic muscle strength in both groups with no between-group differences. Conclusion. Experimental knee joint pain improved the training-induced gain in muscle strength following 8 weeks of quadriceps training. It remains to be studied whether knee joint pain has a positive effect on strength gain in patients with knee pathology.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Significance and Innovationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: A randomized controlled trial

Sørensen¹,

Langberg²,

Hodges³

et al. 2011

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

Evaluation of the Benefit of Corticosteroid Injection Before Exercise Therapy in Patients With Osteoarthritis of the Knee

et al. 2015

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Decreased grip strength, muscle pain, and atrophy occur in rats following long‐term exposure to excessive repetitive motion

et al. 2017

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Work‐related musculoskeletal disorders (WMSD) are caused by the overuse of muscles in the workplace. Performing repetitive tasks is a primary risk factor for the development of WMSD. Many workers in highly repetitive jobs exhibit muscle pain and decline in handgrip strength, yet the mechanisms underlying these dysfunctions are poorly understood. In our study, rats performed voluntary repetitive reaching and grasping tasks (Task group), while Control group rats did not perform these activities. In the Task group, grip strength and forearm flexor withdrawal threshold declined significantly from week 2 to week 6, compared with these values at week 0 (P < 0.05). Relative muscle weight and muscle fiber cross‐sectional area of flexor digitorum superficialis (FDS) muscles decreased significantly in the Task group, compared with the Control group, at 6 weeks (P < 0.05 and P < 0.01, respectively). Nerve growth factor, glial cell line‐derived neurotrophic factor, and tumor necrosis factor α‐expression in FDS muscles were not significantly different in Control and Task groups at 3 and 6 weeks. At 6 weeks, the Task group had elevated MuRF1 protein levels (P = 0.065) and significant overexpression of the autophagy‐related (Atg) proteins, Beclin1 and Atg5–Atg12, compared with in the Control group (both P < 0.05). These data suggested that long‐term exposure to excessive repetitive motion causes loss of grip strength, muscle pain, and skeletal muscle atrophy. Furthermore, this exposure may enhance protein degradation through both the ubiquitin‐proteasome and autophagy‐lysosome systems, thereby decreasing skeletal muscle mass.

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Experimental Knee Pain Reduces Muscle Strength

Cited by 131 publications

References 36 publications

Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: A randomized controlled trial

Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: A randomized controlled trial

Evaluation of the Benefit of Corticosteroid Injection Before Exercise Therapy in Patients With Osteoarthritis of the Knee

Decreased grip strength, muscle pain, and atrophy occur in rats following long‐term exposure to excessive repetitive motion

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