Experimental Investigation on the Effects of Trauma and Traumatic Shock on Gastro-Intestinal Motility and Secretions

Necheles, H.; Olson, Wm. H.

doi:10.1152/ajplegacy.1942.136.1.32

Cited by 6 publications

(1 citation statement)

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“…Furthermore they are inevita-G UISAN/ H rkno/G ur d ble after small bowel transplantation [2,4,11,17]. The behavior of the intestine after ischemia has been the subject of conflicting reports, motili ty inhibition being observed by some workers, stimulation by others [7,10,13,15,16,18], Estimation of the spontaneous intrinsic motility as the sole measure of intestinal motor function can be misleading [5], As shown by H ukuhara et al [8] the peristaltic reflex can be elicited by chemical stimulation of the mucosa. We have designed a method in order to study the motor re sponse to intraluminal mucosal stimulation in the awake animal.…”

Section: Introductionmentioning

confidence: 99%

Effect of Acute Ischemia on the Motility of the Small Bowel in the Awake Dog

Y¹,

Hreno²,

Gurd³

1975

Eur Surg Res

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The effect of acute ischemia obtained by clamping the feeding arteries was studied on a 30-cm loop of upper jejunum in mongrel dogs. In order to eliminate the side-effects of anesthetics on the small bowel, the studies were performed on the awake dog, where access to the upper jejunum was permitted by the construction of a jejunostomy with a Roux-en-Y anastomosis for reestablishment of intestinal continuity. The motility was estimated after stimulation of the mucosa with a standard bolus of isotonic 0.1 NHC1. This technique presented the advantage of a much higher reproducibility than the usual recordings of the spontaneous motility alone. Acute ischemia caused an immediate hyperexcitability of the segment of jejunum under study despite complete destruction of the mucosa followed by an irregular hyperexcitable pattern during the first 48 h after injury. The controls on the other hand presented a strongly diminished response to stimulation with a slow recovery.

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