(1) Background: In the past, sound design was focused on the minimization of the emitted sound, understanding that the lower the sound, the better. Nowadays, this concept is outdated; in addition to the sound pressure level, many more aspects of the sound are considered to fulfil the subjective satisfaction of clients. Thus, a new concept called sound quality has emerged to reach more facets of the sound. In refrigeration systems, the recommendations of European Union are aimed at reducing greenhouse emissions by means of the replacement of the hydrochlorofluorocarbons gases with other less pollutant gases. The refrigeration systems are designed to be used with a specific refrigeration gas, and the noise emitted by these systems is certificated using this refrigeration gas. However, the regularizations have changed, and new refrigerant gases should be used. Considering that these new refrigeration gases work at different pressures, it is possible that the noise could be different with these gases. Moreover, the study of sound quality is very important for the manufacture as the perception and therefore the annoyance could change with the use of new gases. (2) Methods: Two different gases, R-449A and R-134A, have been studied. An acoustic camera has been used to measure and identify the sound quality in the refrigeration systems. (3) Results: The results have shown R-134A has better sound quality than R-449A. (4) Conclusions: This study shows that R-449A and R-134A could be a substitute for R-404A in terms of noise level.