This paper demonstrates the advantages and prospects of transparent design of the heating surface for the simultaneous study of the hydrodynamic and thermal characteristics of spray cooling. It was shown that the high-speed recording from the reverse side of such heater allows to identify individual droplets before their impact on the forming liquid film, which makes it possible to measure their sizes with high spatial resolution. In addition, such format enables one to estimate the number of droplets falling onto the impact surface and to study the features of the interface evolution during the droplets’ impacts. In particular, the experiments showed various possible scenarios for this interaction, such as the formation of small-scale capillary waves during impacts of small droplets, as well as the appearance of “craters” and splashing crowns in the case of large ones. Moreover, the unsteady temperature field during spray cooling in regimes without boiling was investigated using high-speed infrared thermography. Based on the obtained data, the intensity of heat transfer during spray cooling for various liquid flow rates and heat fluxes was analyzed. It was shown that, for the studied regimes, the heat transfer coefficient weakly depends on the heat flux density and is primarily determined by the flow rate. In addition, the comparison of the processes of spray cooling and nucleate boiling was made, and an analogy was shown in the mechanisms that determine their intensity of heat transfer.