The space-time whitened matched filter (ST-WMF) maximum likelihood sequence detection (MLSD) architecture has been recently proposed (Maggio et al., 2014). Its objective is reducing implementation complexity in transmissions over nonlinear dispersive channels. The ST-WMF-MLSD receiver (i) drastically reduces the number of states of the Viterbi decoder (VD) and (ii) offers a smooth trade-off between performance and complexity. In this work the ST-WMF-MLSD receiver is investigated in detail. We show that the space compression of the nonlinear channel is an instrumental property of the ST-WMF-MLSD which results in a major reduction of the implementation complexity in intensity modulation and direct detection (IM/DD) fiber optic systems. Moreover, we assess the performance of ST-WMF-MLSD in IM/DD optical systems with chromatic dispersion (CD) and polarization mode dispersion (PMD). Numerical results for a 10 Gb/s, 700 km, and IM/DD fiber-optic link with 50 ps differential group delay (DGD) show that the number of states of the VD in ST-WMF-MLSD can be reduced ∼4 times compared to an oversampled MLSD. Finally, we analyze the impact of the imperfect channel estimation on the performance of the ST-WMF-MLSD. Our results show that the performance degradation caused by channel estimation inaccuracies is low and similar to that achieved by existing MLSD schemes (∼0.2 dB).