Experimental intestinal reovirus infection of mice

Abstract

Reovirus, a member of the Reoviridae family, is a ubiquitous virus in vertebrate hosts. Although disease caused by reovirus infection is for the most part mild, studies of reovirus have been particularly valuable as a model for understanding the local host response to replicating foreign antigen in intestinal and respiratory sites. In this article, a brief overview is presented of the basic features of reovirus infection, as will the host's humoral and cellular immune response to during the infectious cycle. New information regarding the interactions and involvement of immune response molecules during reovirus infection will be presented based on multiple analyte array studies from our laboratory.

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus

“…It should be noted that in new-born mice, which are immune compromised, reovirus can cause lethal encephalitis, bile-duct atresia, and vasculitis [ 20 ]. The pathogenicity of reovirus infection in mice has been reviewed by Montufar-Solis and Klein in 2005 [ 117 ].…”

Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection

“…Presumably, the action of sgp130 would be to block IL-6 trans-signaling to intestinal leukocytes and enterocytes that are a source of chemotactic mediators and receptors that contribute to the inflammatory process (Adams and Eksteen, 2006; Rivera-Nieves et al, 2006). In a previous study from our laboratory we demonstrated, using a protocol for detecting twenty-two immune response analytes (chemokines and cytokines), that thirteen were produced at elevated levels by day 4 post-infection (Montufar-Solis and Klein, 2005). Among those analytes were several that are known to drive the inflammatory response (IL-6, IL-12, IL-17, IFN-γ, GM-CSF, and MCP-1).…”