“…Presumably, the action of sgp130 would be to block IL-6 trans-signaling to intestinal leukocytes and enterocytes that are a source of chemotactic mediators and receptors that contribute to the inflammatory process (Adams and Eksteen, 2006; Rivera-Nieves et al, 2006). In a previous study from our laboratory we demonstrated, using a protocol for detecting twenty-two immune response analytes (chemokines and cytokines), that thirteen were produced at elevated levels by day 4 post-infection (Montufar-Solis and Klein, 2005). Among those analytes were several that are known to drive the inflammatory response (IL-6, IL-12, IL-17, IFN-γ, GM-CSF, and MCP-1).…”