Experimental infection of sheep and goats with a recent isolate of peste des petits ruminants virus from Kurdistan

Wernike, Kerstin; Eschbaumer, Michael; Breithaupt, Angele; Maltzan, Julia; Wiesner, Henning; Beer, Martin; Hoffmann, Bernd

doi:10.1016/j.vetmic.2014.05.010

Cited by 29 publications

(43 citation statements)

References 17 publications

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“…Clinical signs in PPRV-infected sheep (trial 4) were generally mild to moderate, as previously described ( 3 , 8 ). Contact controls showed similar clinical signs.…”

Section: The Studysupporting

confidence: 67%

See 1 more Smart Citation

Neglected Hosts of Small Ruminant Morbillivirus

Schulz¹,

Fast²,

Schlottau³

et al. 2018

Emerg. Infect. Dis.

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“…Clinical signs in PPRV-infected sheep (trial 4) were generally mild to moderate, as previously described ( 3 , 8 ). Contact controls showed similar clinical signs.…”

Section: The Studysupporting

confidence: 67%

“…In 4 trials (trials 1–4; Table) we intranasally inoculated suids with a recent PPRV-LIV strain (Kurdistan/2011 [ 7 , 8 ]). Contact control animals were added 2 days later.…”

Section: The Studymentioning

confidence: 99%

Neglected Hosts of Small Ruminant Morbillivirus

Schulz¹,

Fast²,

Schlottau³

et al. 2018

Emerg. Infect. Dis.

Self Cite

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“…Reduced virulence of the infectious challenge was observed in this study compared to other experimental infections with PPRV (El Harrak et al., ; Hammouchi et al., ; Wernike et al., ). It was unlikely due to the strain Maroc/2008 itself, which was able to determine severe clinical disease after experimental inoculation in goat (Hammouchi et al., ), nor to the intranasal route of inoculation (El Harrak et al., ).…”

Section: Discussionsupporting

confidence: 47%

Evaluation of Humoral Response and Protective Efficacy of an Inactivated Vaccine Against Peste des Petits Ruminants Virus in Goats

Cosseddu

Polci

Pinoni

et al. 2015

Transbound Emerg Dis

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Four goats were inoculated with an inactivated peste des petits ruminants virus (PPRV) vaccine. Three unvaccinated goats were kept as controls. After 36 days, the four goats were revaccinated. The immune response was monitored by virus neutralization test showing that two doses of the vaccine were able to stimulate strong immune response in all the vaccinated animals. The vaccinated goat and the controls were challenged with virulent PPRV intranasally. After PPRV challenge, the three control goats showed fever, viremia and virus excretion through mucosal surfaces, whereas the vaccinated goats were fully protected against PPRV infection and replication.

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“…Examining small ruminant susceptibility Previous reports have suggested that goats may be more severely affected than sheep by PPRV infection [21][22][23]. However, variation in disease severity has also been observed between different species of goats [24,25], and detailed research is required to define this susceptibility and whether the variation extends to specific features such as the duration of viral shedding in infected animals, which will contribute to the dynamics of PPR transmission.…”

Section: Pprv Virology and Epidemiology: Improving Our Fundamental Unmentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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Experimental infection of sheep and goats with a recent isolate of peste des petits ruminants virus from Kurdistan

Cited by 29 publications

References 17 publications

Neglected Hosts of Small Ruminant Morbillivirus

Neglected Hosts of Small Ruminant Morbillivirus

Evaluation of Humoral Response and Protective Efficacy of an Inactivated Vaccine Against Peste des Petits Ruminants Virus in Goats

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

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