Experimental infection of mice with Toxocara canis larvae obtained from Japanese quails

Pahari, T.K.; Sasmal, N. K.

doi:10.1016/0020-7519(90)90110-9

Cited by 15 publications

(10 citation statements)

References 12 publications

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“…Larvae of T. canis can be transmitted also from one paratenic host to another. Okoshi and Usui (1968) reported larval toxocarosis in mice inoculated with larvae originating from mouse or chickens and Pahari and Sasmal (1990) observed a similar situation in mice after infection with larvae originating from Japanese quails. Taira et al (2004) successfully infected pigs with larvae originating from fresh swine or poultry viscera containing Toxocara larvae.…”

Section: Introductionmentioning

confidence: 69%

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

et al. 2011

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Using a small animal imaging system, migratory activity of Toxocara canis larvae stained by carboxyfluorescein succinimidyl ester (CFSE) was observed post primary infection (PPI) and post reinfection (PR) of BALB/c mice. Each infection was performed with 1,000 larvae per mouse. Primary infections were performed with labeled larvae, while for challenge infections the reinfecting larvae were stained by CFSE. The worm burden in mouse organs was determined during a period from 6 h to 21 days and 4 months PPI and PR. In comparison with primary infections that led to the first larvae appearance in the brain after 60 h, greatly accelerated migration of the parasites administered 3 weeks PPI to the CNS and eyes of challenged mice was noted-in both organs the larvae appeared 6 h PR. In all challenged mice, reinfecting larvae prevailed in the resident parasite population. Preliminary experiments with Toxocara cati larvae also revealed early brain involvement in primarily infected mice. Staining of T. canis larvae by CFSE had no effect on the development of a humoral antibody response against T. canis excretory-secretory antigens. In ELISA, elevated levels of specific IgG and IgG1 were noted on day 14 PPI and the levels of antibodies increased till the end of experiment. Reinfection induced an increase in the levels of both antibodies. In terms of optical density, IgG1 antibodies gave higher values in all sera examined. In ELISA for IgG antibodies, an increase in the avidity index of around 50% was detected 1 month PPI; higher-avidity antibodies were also detected in sera of reinfected animals.

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Section: Introductionmentioning

confidence: 69%

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

et al. 2011

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“…These encapsulated larvae in animal tissues do not grow into adult worms, but are capable of transmitting to other animals that eat the infected tissues harboring encapsulated larvae. This mode of transmission among carnivorous vertebrates has been established with experimental studies [1,[3][4][5]. A large variety of non-canine animals can be infected with T. canis.…”

Section: Introductionmentioning

confidence: 99%

Toxocariasis and Ingestion of Raw Cow Liver in Patients with Eosinophilia

et al. 2008

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Ingestion of raw animal liver has been suggested as a possible mode of infection of human toxocariasis. We evaluated the relationship between toxocariasis and the ingestion of raw meat in patients with eosinophilia of unknown etiology. The study population consisted of 120 patients presenting with peripheral blood eosinophilia (> 500 cells/ l or > 10% of the white blood cell count). They were divided into 2 groups: 104 seropositive patients based on a Toxocara excretory-secretory IgG ELISA and 16 seronegative patients. While 25.0% of seronegative patients had a recent history of eating raw cow liver, 87.5% of seropositive patients had this history. Multivariate statistical analysis showed that a recent history of eating raw cow liver was related to an increased risk of toxocariasis. Collectively, it is proposed that raw cow liver is a significant infection source of toxocariasis in the patients with eosinophilia of unknown etiology.

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“…The zoonotic significance of Toxocara canis larvae is of prime interest considering its strong tendency to cause ‘visceral larva migrans’ (VLM) in abnormal hosts, including humans, which act as paratenic hosts of T. canis . Toxocara canis larvae persist for months or years in a wide range of mammalian laboratory hosts (Pahari & Sasmal, 1990a) and it is presumed that they are transferred from animal to animal through paratenism in nature (Sprent, 1954; Pahari & Sasmal, 1990b). With regard to the role of invertebrates, Sprent (1956), Okoshi & Usui (1968) and Pahari & Sasmal (1991) reported successful infections of earthworms with T. cati and T. canis and the establishment of patent infections in the definitive host.…”

Section: Introductionmentioning

confidence: 99%

Experimental infection of the cockroachPeriplaneta americanawithToxocara canisand the establishment of patent infections in pups

2008

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The possible role of the cockroach Periplaneta americana in the transmission of Toxocara canis eggs and larvae via faeces and tissue migration was studied. Cockroaches fed with 3 x 105 and 5 x 105 embryonated eggs were found to harbour viable eggs and larvae from days 1 to 5 post-infection (DPI). At necropsy on 5 DPI, eggs and larvae were also recovered from the rectal contents but not from the tissues of cockroaches. In addition patent infections were established in pups fed on infected faeces of cockroaches, with eggs first appearing in the faeces of pups at 38 DPI. Adult worms of T. canis were also recovered at necropsy. Therefore the importance of cockroaches as good mechanical disseminators of ascarid eggs, especially T. canis, is discussed.

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Experimental infection of mice with Toxocara canis larvae obtained from Japanese quails

Cited by 15 publications

References 12 publications

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS

Toxocariasis and Ingestion of Raw Cow Liver in Patients with Eosinophilia

Experimental infection of the cockroachPeriplaneta americanawithToxocara canisand the establishment of patent infections in pups

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