Experimental Infarction of the Immature Canine Femoral Head

Freeman, M. A. R.; England, J P S

doi:10.1177/003591576906200508

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Between 2 and 3 weeks post-surgery, hypervascularization was noted. Freeman and colleagues modified this model to include dislocation and thermal coagulation of the blood vessels entering the epiphysis in skeletally immature mongrel puppies [10][11][12]. Freeman and England [12] divided the ligamentum teres, dislocated the hip, and coagulated the soft tissue of the femoral neck.…”

Section: Animal Models Of Perthes Diseasementioning

confidence: 99%

“…Rowe et al [20] Cutting the ligamentum teres, ligating the femoral neck 4-5-week-old piglets Zahir et al [11] Sanchis et al [10] Hip dislocation and coagulation 1-month-old puppies Kamegaya et al [15] Electrocoagulated epiphyseal artery and subluxation and dislocation secondary to immobilization 4-5-week-old white rabbits Freeman and England [12] Hip dislocation and ligamentum teres rupture and coagulation and SS wire cerclage 8-10-week-old puppies Rowe et al [16] Ligamentum teres resection, ligating the femoral neck, immobilizing the knee joint 4-5-week-old rabbits…”

Section: Animal Models Of Perthes Diseasementioning

confidence: 99%

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Animal Models of Osteonecrosis

Jones

Allen

2011

Clinic Rev Bone Miner Metab

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Section: Animal Models Of Perthes Diseasementioning

confidence: 99%

Section: Animal Models Of Perthes Diseasementioning

confidence: 99%

Animal Models of Osteonecrosis

Jones

Allen

2011

Clinic Rev Bone Miner Metab

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“…To establish a traumatic ONFH model, several methods for blocking the blood supply to the femoral head have been reported; these involve tightening the femoral blood vessels, circulation of liquid nitrogen around the femoral head, and dislocation of the hip and detachment of the soft tissue [3], [4], [5], [6], [7], [8], [9]. Nishino et al .…”

Section: Introductionmentioning

confidence: 99%

HGF-Transgenic MSCs Can Improve the Effects of Tissue Self-Repair in a Rabbit Model of Traumatic Osteonecrosis of the Femoral Head

et al. 2012

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BackgroundOsteonecrosis of the femoral head (ONFH) is generally characterized as an irreversible disease and tends to cause permanent disability. Therefore, understanding the pathogenesis and molecular mechanisms of ONFH and developing effective therapeutic methods is critical for slowing the progress of the disease.Methodology/Principal FindingsIn this study, an experimental rabbit model of early stage traumatic ONFH was established, validated, and used for an evaluation of therapy. Computed tomography (CT) and magnetic resonance (MR) imaging confirmed that this model represents clinical Association Research Circulation Osseous (ARCO) phase I or II ONFH, which was also confirmed by the presence of significant tissue damage in osseous tissue and vasculature. Pathological examination detected obvious self-repair of bone tissue up to 2 weeks after trauma, as indicated by revascularization (marked by CD105) and expression of collagen type I (Col I), osteocalcin, and proliferating cell nuclear antigen. Transplantation of hepatocyte growth factor (HGF)-transgenic mesenchymal stem cells (MSCs) 1 week after trauma promoted recovery from ONFH, as evidenced by a reversed pattern of Col I expression compared with animals receiving no therapeutic treatment, as well as increased expression of vascular endothelial growth factor.Conclusions/SignificanceThese results indicate that the transplantation of HGF-transgenic MSCs is a promising method for the treatment for ONFH and suggest that appropriate interference therapy during the tissue self-repair stage contributes to the positive outcomes. This study also provides a model for the further study of the ONFH etiology and therapeutic interventions.

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Opinions on and comparative observations about the etiology of Legg-Calv�-Perthes disease

Batory¹

1982

Arch. Orth. Traum. Surg.

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The article describes the various opinions on the etiology of Legg-Calvé-Perthes disease: 1. The theory of double infarction. 2. The theory of venous stasis. 3. The latent prolonged ischemic phase. Due to the varying development of the vasculature of the proximal end of the femur, with a diminishing number of arteries ensuring blood supply and the subsequent reduction in the speed of flow in the myeloic sinuses, we describe here the origin of the latent ischemic phase of the proximal epiphysis of the femur, which constitutes the predisposition for the development of Perthes' disease. In the discussion about the diverse alterations connected with Legg-Calvé-Perthes disease, like the retardation of skeletal maturity, the dysplasia capitis or the necrosis following the treatment of congenital hip luxation, the different interpretations about the etiology of Perthes' disease are compared.

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Experimental Infarction of the Immature Canine Femoral Head

Cited by 6 publications

References 2 publications

Animal Models of Osteonecrosis

Animal Models of Osteonecrosis

HGF-Transgenic MSCs Can Improve the Effects of Tissue Self-Repair in a Rabbit Model of Traumatic Osteonecrosis of the Femoral Head

Opinions on and comparative observations about the etiology of Legg-Calv�-Perthes disease

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