Experimental induction of pneumonic pasteurellosis in calves by intratracheal infection with Pasteurella multocida biotype A:3

Application of acute phase protein measurements in veterinary clinical chemistry

“…The magnitude of the response was similar, but the duration was longer in the coinfection group reflecting the duration of the clinical symptoms. Recently, experimental induction of pneumonia by inoculation of P. multocida has shown that a high challenge volume irrespective of the number of bacteria is associated with increased plasma haptoglobin concentrations [33]. However, despite this association, a significantly higher mean post-infection Hp concentration was also observed when compared to the mean preinfection concentration.…”

“…Banding is not associated with changes in the Hp concentration [41], whereas castration is followed by an increased Hp level Cattle Experimental local aseptic inflammation [22,28] Infection with bovine virus diarrhea virus and Pasteurella haemolytica [61] Experimental infection with P. multocida [33] Experimental infection with P. haemolytica [87] Infection with bovine herpes virus 1 and P. haemolytica A1 [58] Experimental infection with bovine respiratory syncytial virus [65] Natural infections with foot-and-mouth disease virus [81] Mastitis [40,68,70,130,152] Various acute infections under field conditions [164] Clinical respiratory tract disease [188] Various inflammatory diseases [6] Acute inflammations [104] Castration [35,47,50,51,52] Ruminotomy [119] Metritis [71,165,166] Severe uterine bacterial post partum contamination [160] Fatty liver (hepatic lipidosis) [87,124,192] Nonfeeding for 3 days [88] Starvation for 2 days combined with Dexamethasone treatments [193] Transportation for 2 days [120] Major injuries at slaughter/culling [69,149] Horse Experimental aseptic arthritis [80] Experimental local aseptic inflammation [113,171] Experimentally induced noninfectious ...…”

Experimental Infection of Calves with Pasteurella multocida Serovar A:3 Isolated in Japan

“…The pathogenicity of capsular type A has not been clearly defined. There are several reports on experimental infections of calves with a strain of serovar A: 3 [4,6]. However, these required large doses to reproduce pneumonic lesions.…”

“…In previous experimental infections, only one strain of P. multocida was used [2,4,6,11], therefore any differences among strains remain unknown. A high inoculation dose of 10 10 CFU/ml and high inoculation volumes of 50-300 ml were required to produce serious pneumonic lesions [4,6,11].…”

“…A high inoculation dose of 10 10 CFU/ml and high inoculation volumes of 50-300 ml were required to produce serious pneumonic lesions [4,6,11]. Lower doses and volumes resulted in only mild disease [2].…”