Experimental Hypertrophy and Atrophy of the Prostate Gland

McCullagh, D. Roy; Walsh, E. L.

doi:10.1210/endo-19-4-466

Cited by 28 publications

(3 citation statements)

References 3 publications

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“…The testicles are capable of producing gonadal peptide hormones. McCullagh and Walsh (1935) postulated existence of a nonsteroidal gonadally produced substance that inhibited the pituitary secretion of FSH and called it inhibin. Inhibin is a peptide produced by the Sertoli cells (under LH stimulus) and occurs in two subtypes: Inhibin A and Inhibin B.…”

Section: Testicular Structure and Functionmentioning

confidence: 99%

Physiology and Endocrinology of Hot Flashes in Prostate Cancer

Engstrom

Kasper

2007

Am J Mens Health

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Section: Testicular Structure and Functionmentioning

confidence: 99%

Physiology and Endocrinology of Hot Flashes in Prostate Cancer

Engstrom

Kasper

2007

Am J Mens Health

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“…Could the estrogenic hormones be replaced by androgens or by progesterone? Experimental studies have indicated that androgenic preparations are able to limit the secretion of gonadotropic complex by the anterior pituitary (7,8,9,10,11,12). It is true that estrone possesses a greater efficiency in limiting the gonadotropic activity of the pituitary than the androgens.…”

Section: Resultsmentioning

confidence: 99%

The Menopause a Consideration of the Symptoms, Etiology, and Treatment by Means of Estrogens

Wiesbader

Kurzrok

1938

Endocrinology

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NEW YORK CITYThe treatment of menopause symptoms by ovarian extracts dates back a full generation, but therapy by means of pure hormone preparations is of very much more recent origin. Large quantities of pure estrogens have become available only during the past 5 years. This report deals with the treatment of 200 cases of menopause by means of purified or crystalline estrogenic hormones (except one). These patients have been observed over a period of not less than 6 months and, on the average, not more than 3 years years. Several patients have been observed for about 4 years.Distribution of cases. The etiological factors in the causation of the menopause have been as follows: spontaneous menopause, 160 cases; surgical menopause, 34 cases; radiation menopause, 6 cases. SYMPTOMATOLOGYIn every case an attempt was made to determine the predominant symptom that brought the patient to the Clinic. Other symptoms were also carefully noted. The symptoms were as follows.Disturbances of menstruation. Amenorrhea was one of the most common complaints. Twenty-nine patients were still menstruating, but presented other symptoms characteristic of the menopause. Of this group 18 patients reported fairly regular periods, whereas in the remaining the bleeding ranged from oligomenorrhea to hyper-polymenorrhea. It was interesting to note the effect of menstruation (or bleeding) on the symptoms. In 12 cases the symptoms definitely improved with bleeding, in 8 cases the symptoms were made worse, and in the remainder no difference was observed.Neurovascular disturbances. These were observed in almost all patients to a greater or less degree. The symptoms were hot flushes, sweats, palpitations, sleeplessness, numbness or tingling in the extremities and sensory neuroses especially of the throat. Hypertension appeared rather frequently. In view of the fact that many of the patients were not seen by us prior to treatment, it was very difficult to determine to what extent the hypertension was solely attributable to the menopause. If as a result of 4 weeks treatment there 32 The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 14 July 2015. at 08:55 For personal use only. No other uses without permission. . All rights reserved.

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“…This is particularly true of the experiment 9 s^.^^I n the experiment cf sf, the accessory organs of the castrated male remain atrophic. However, according to McCullagh and Walsh (1935), the injection of a comb-growth-stimulating hormone ("androtin") prevents both a gonadotropic effect in the normal male and a regression of the accessory organs in the castrated male.^^De Mello (1936) placed an ovarian graft in the normal male of the parabiotic pair^cT. A hypertrophy of the prostate and seminal vesicles of the normal male, abnormal even for such an experiment, apparently was caused by the combined effects of ovarian and testicular secretions.…”

Section: Special Considerationsmentioning

confidence: 99%

The Physiology and Pharmacology of the Pituitary Body.

1937

Arch Intern Med

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The Pituitary Body in Relation to the Regulation of the Distribution OF Pigment IN Chromatophores . . . 244 IX. New Observations on the Chemistry and Pharmacology OF Extracts of the Pars Neuralis 258 X. The Pars Neuralis as a Gland of Internal Secretion . 274 Appendix. The Structural Formulas and Principal Actions OF Hormones of Natural Origin Bibliography Index 51955 ' Whether or not a pars intermedia can be identified in the bird's pituitary is still undecided (see the discussion of Wislocki and Gelling).f 10]''' Testosterone or androstenedione can cause ovulation by acting on the excised ovary of the toad, X. laevis .

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Experimental Hypertrophy and Atrophy of the Prostate Gland

Cited by 28 publications

References 3 publications

Physiology and Endocrinology of Hot Flashes in Prostate Cancer

Physiology and Endocrinology of Hot Flashes in Prostate Cancer

The Menopause a Consideration of the Symptoms, Etiology, and Treatment by Means of Estrogens

The Physiology and Pharmacology of the Pituitary Body.

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