Physiology and Endocrinology of Hot Flashes in Prostate Cancer

Engstrom, Christine; Kasper, Christine E.

doi:10.1177/1557988306294162

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…Constriction and dilation of blood vessels is the primary method by which core body temperature is adjusted. 25 Findings for other SNPs are in line with previous studies showing associations between neurotransmission and inflammation 26 as well as between inflammation and hot flashes. 27, 28 The potential role of mutations on genes associated with vasoconstriction, neurotransmission, and immune function in moderating the impact of ADT on HFI merits further investigation.…”

Section: Discussionsupporting

confidence: 86%

Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison

et al. 2015

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Purpose Many men receiving androgen deprivation therapy (ADT) for prostate cancer experience hot flashes. This study aimed to describe the course of hot flash interference (HFI) over time in ADT recipients relative to matched prostate cancer and cancer-free controls, from before the start of ADT to 12 months later. We also examined demographic, clinical, and genetic predictors of the impact of ADT on hot flash interference. Materials and Methods Three groups were examined: prostate cancer patients recruited before or within 21 days of starting ADT (n=60), age- and education-matched prostate cancer patients treated with prostatectomy only (n=83), and age- and education-matched men with no history of cancer (n=86). Participants provided blood samples and completed the Hot Flash Daily Interference Scale at baseline as well as 6 and 12 months later. Results ADT recipients reported increasing HFI over time relative to controls (p<.001). Group differences were evident at 6 and 12 months (ps<.001), with ADT recipients reporting greater HFI than controls. Several genetic polymorphisms were found to predict greater increases in HFI (ps<.01), including polymorphisms on genes associated with vasoconstriction, immune function, neurotransmission, and circadian rhythms. ADT recipients who were younger and had lower body mass index at baseline also exhibited greater increases in HFI over time (ps≤.01). Conclusions This study, the first to prospectively examine HFI in ADT recipients, found that those with certain genetic polymorphisms, younger age, and lower BMI had greater increases in HFI over time relative to controls.

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Section: Discussionsupporting

confidence: 86%

Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison

et al. 2015

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“…Hot flashes are troublesome vasomotor symptoms caused by gender hormone withdrawal that can be caused by androgen depravation therapy (ADT) [2], in breast cancer survivors after chemo/hormonal therapy [3], or naturally in menopausal women [4]. Several reports show that hot flashes are identical in both sexes [5,6] making their study a model disease condition for the evaluation of medical and non-pharmacologic interventions. Along with the vasomotor events, a constellation of other debilitating symptoms occur including fatigue, weight gain, anxiety and depression, loss of libido, and changes of patterns or disruption of sleep.…”

Section: Where Do Hot Flashes (An Autonomic Disorder) Come From?mentioning

confidence: 99%

Intermittent 96 Hour Auricular Electro Acupuncture Using Microcurrent Stimulation for Symptoms of Hot Flashes: Effective Autonomic Modulation?

Rich¹

2017

IJCAM

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Described here is a new treatment approach for hot flashes with Auricular Electroacupuncture (AEA) using an intermittent 96 hour micro current treatment protocol. This has been tested in a group of men with advanced prostate cancer suffering from vasomotor symptoms (hot flashes) induced by androgen depravation therapy. All subjects were monitored with repeated heart rate variability (HRV) measurements over a six week protocol. The results of the AEA intervention show excellent reduction of hot flash symptoms, along with improved quality of life and sleep. Reviewed here are aspects of this treatment protocol that support continued research with AEA for this model disease that has pathophysiologic underpinnings of dysfunctional autonomic nervous system activity. The improvement of clinical symptoms with AEA intervention may represent autonomic modulation resulting from a balanced sympathetic and parasympathetic activity produced by prolonged auricular vagal nerve stimulation.

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“…Symptoms occur in 50–80% of men undergoing ADT and are considered the most bothersome symptom among 27% of patients . Although the exact etiology for vasomotor symptoms with ADT remains unclear, it may be related to the absence of negative feedback from sexual hormones on the hypothalamus, resulting in thermoregulatory dysfunction and neurogenic‐mediated vascular dilation .…”

Section: Adverse Effects Of Adtmentioning

confidence: 99%

Androgen Deprivation Therapy Impact on Quality of Life and Cardiovascular Health, Monitoring Therapeutic Replacement

Trost

Şerefoğlu

Gökçe

et al. 2013

The Journal of Sexual Medicine

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Introduction Androgen deprivation therapy (ADT) is commonly utilized in the management of both localized and advanced adenocarcinoma of the prostate. The use of ADT is associated with several adverse events, physical changes, and development of medical comorbidities/mortality. Aim The current article reviews known adverse events associated with ADT as well as treatment options, where available. Current recommendations and guidelines are cited for ongoing monitoring of patients receiving ADT. Methods A PubMed search of topics relating to ADT and adverse outcomes was performed, with select articles highlighted and reviewed based on level of evidence and overall contribution. Main Outcome Measures Reported outcomes of studies detailing adverse effects of ADT were reviewed and discussed. Where available, randomized trials and meta-analyses were reported. Results ADT may result in several adverse events including decreased libido, erectile dysfunction, vasomotor symptoms, cognitive, psychological and quality of life impairments, weight gain, sarcopenia, increased adiposity, gynecomastia, reduced penile/testicular size, hair changes, periodontal disease, osteoporosis, increased fracture risk, diabetes and insulin resistance, hyperlipidemia, and anemia. The definitive impact of ADT on lipid profiles, cardiovascular morbidity/mortality, and all-cause mortality is currently unknown with available data. Treatment options to reduce ADT-related adverse events include changing to an intermittent treatment schedule, biophysical therapy, counseling, and pharmacotherapy. Conclusions Patients treated with ADT are at increased risk of several adverse events and should be routinely monitored for the development of potentially significant morbidity/mortality. Where appropriate, physicians should reduce known risk factors and counsel patients as to known risks and benefits of therapy.

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Physiology and Endocrinology of Hot Flashes in Prostate Cancer

Cited by 5 publications

References 66 publications

Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison

Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison

Intermittent 96 Hour Auricular Electro Acupuncture Using Microcurrent Stimulation for Symptoms of Hot Flashes: Effective Autonomic Modulation?

Androgen Deprivation Therapy Impact on Quality of Life and Cardiovascular Health, Monitoring Therapeutic Replacement

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