Experimental Hydroxyapatite Cement Cranioplasty

Costantino, Peter D.; Friedman, Craig D.; Jones, Kent; Chow, Laurence C.; Sisson, George A.

doi:10.1097/00006534-199290020-00003

Cited by 255 publications

(75 citation statements)

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“…Thus, these scientists inadvertently discovered a new type of self-hardening cements that consisted of only calcium phosphates and formed HA as the product12. In subsequent years, results from a series of animal studies15,16,17 demonstrated that because CPC formed biocompatible, precipitated nano-crystalline HA as the product, implanted CPC was gradually replaced by new bone without a loss in volume. This CPC composition received approval by the US Food and Drug Administration in 1996, thus becoming the first commercially available CPC for use in humans.…”

Section: Calcium Phosphate Cementsmentioning

confidence: 99%

Next generation calcium phosphate-based biomaterials

2009

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It has been close to a century since calcium phosphate materials were first used as bone graft substitutes. Numerous studies conducted in the last two decades have produced a wealth of information on the chemistry, in vitro properties, and biological characteristics of granular calcium phosphates and calcium phosphate cement biomaterials. An in depth analysis of several key areas of calcium phosphate cement properties is presented with the aim of developing strategies that could lead to break-through improvements in the functional efficacies of these materials.

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Section: Calcium Phosphate Cementsmentioning

confidence: 99%

Next generation calcium phosphate-based biomaterials

2009

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“…] Ein wesentlicher Aspekt, der unmittelbar mit der außerordentlichen Biokompatibilität des Reintitans verknüpft ist, ist die unterstützende, osseokonduktive Wirkung der Titanoberfläche bei Osseointegration im Kontakt mit Knochengewebe. Er ist für die lastfreie, kranio-faziale Knochenrekonstruktion geeignet und wird seit 2 Jahren mit bisher guten Resultaten klinisch getestet [8,30]. Titan wird in verschiedenen Zusammensetzungen (Grade I bis Grade V) angeboten, die sich zwar nicht in ihrer Biokompatibilität, dafür aber deutlich in ihren mechanischen Eigenschaften unterscheiden (Tabelle 3).…”

Section: Keramikwerkstoffe Und Bioaktive Gläserunclassified

Implantatmaterialien für Mittelohr und Mastoid

Lehner¹

1997

HNO

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“…CaPs with solubility above that of HAP are reactive and expected to contribute to bone formation with the aid of osteoblasts. However, despite considerable research efforts, the exact mechanism by which these more soluble CaPs promote osteogenesis remains unclear [9,10,11,12]. The majority of CaP cements are formulated from the solutions containing no ions other than Ca, PO 4 , Na, and/or K. Ca-regulated cell responses and the osteoblast-mediated transport of PO 4 are recognized as the prerequisites for bone mineralization [13,14,15] and cellular receptors for both Ca and PO 4 have been identified [14,16].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Polymeric Materials for Tissue Repair

Bienek

Tutak

Škrtić

2017

JFB

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Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field.

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Experimental Hydroxyapatite Cement Cranioplasty

Cited by 255 publications

References 0 publications

Next generation calcium phosphate-based biomaterials

Next generation calcium phosphate-based biomaterials

Implantatmaterialien für Mittelohr und Mastoid

Bioactive Polymeric Materials for Tissue Repair

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