Experimental Human Trichophyton Mentagrophytes Infections**From the Dermatology Research Division, Letterman Army Institute of Research San Francisco California 94129

Reinhardt, Jeffrey H.; Allen, Alfred M.; Gunnison, Douglas; Akers, William A.

doi:10.1111/1523-1747.ep12676579

Cited by 32 publications

(2 citation statements)

References 8 publications

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“…Although dermatophytes were initially studied in experimental human infections [50], the current most common animal model for studying virulence factors of dermatophytes is the guinea pig [51]. This model has been useful for zoophiles [33, 52–54] but does not provide an accurate infection model for most anthropophilic species [4].…”

Section: Testing the Role Of Putative Virulence Factorsmentioning

confidence: 99%

Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections

Achterman

White

2012

International Journal of Microbiology

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Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors.

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Section: Testing the Role Of Putative Virulence Factorsmentioning

confidence: 99%

Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections

Achterman

White

2012

International Journal of Microbiology

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“…In experimental infections of humans [15], T. mentagrophytes ATCC18748 was applied to the ankles followed by 4-day-continuous occlusion. The time course of the disease was described in fine details as follows.…”

Section: Animal Model Of Tinea Corporismentioning

confidence: 99%

Animal Model of Dermatophytosis

Shimamura

Kubota

Shibuya

2012

Journal of Biomedicine and Biotechnology

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Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host's normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatophytosis and evaluate drug efficacy. However, current animal models have several issues. In the present paper, we surveyed reports about the methodology of the dermatophytosis animal model for tinea corporis, tinea pedis, and tinea unguium and discussed future prospects.

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Bioassays Used in Development of Topical Dosage Forms

Haleblian¹

1976

Journal of Pharmaceutical Sciences

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Experimental Human Trichophyton Mentagrophytes Infections**From the Dermatology Research Division, Letterman Army Institute of Research San Francisco California 94129

Cited by 32 publications

References 8 publications

Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections

Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections

Animal Model of Dermatophytosis

Bioassays Used in Development of Topical Dosage Forms

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