Experimental Evaluation of Ten Clinically Used Arterial Prostheses

Patel, Malay; Arnell, Richard E.; Sauvage, Lester R.; Wu, Hong‐De; Shi, Qun; Wechezak, Arlene R.; Mungin, Dorothy; Walker, Melissa J.

doi:10.1007/bf02000270

Cited by 38 publications

(15 citation statements)

References 6 publications

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“…Also, there were no smooth muscle cells (SMC) present as determined by α‐actin and myosin heavy chain, and no wall transinterstitial tissue was observed. These results are similar to what has been previously shown for ePTFE grafts 30, 36…”

Section: Discussionsupporting

confidence: 92%

Vascular graft healing. III. FTIR analysis of ePTFE graft samples from implanted bigrafts

2004

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A bigraft, composed of a 30-microm internodal distance expanded polytetrafluoroethylene (ePTFE) arterial graft segment and a preclotted polyethylene terephthalate arterial graft segment, was used to study the healing process of two different materials in the same dog. Healing was followed by FTIR-ATR spectroscopy and correlated with ELISA analyses of selected growth factors and matrix proteins. The FTIR analyses of the ePTFE explants from 1 and 3 h; 3, 5, 7, 10, and 14 days; and 4 and 8 weeks showed that the ePTFE grafts did not heal (endothelialize), but appeared to remain in overlapping inflammation and proliferation stages of wound healing. Although FN was found in the fibrin layer coating the luminal surface of the ePTFE, VEGF was not present. The inability of VEGF to complex with FN may be the result of FN binding sites being blocked or hidden by the conformation of the fibrin clot that forms on ePTFE. Also, TGF-beta was not present beyond the initial clot formation at 3 h postimplantation. The absence of these two growth factors may be an important factor in the lack of healing of 30-microm ePTFE grafts, because both were found to be present during the early stages of healing for the preclotted polyester grafts that did endothelialize.

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Section: Discussionsupporting

confidence: 92%

Vascular graft healing. III. FTIR analysis of ePTFE graft samples from implanted bigrafts

2004

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“…Implantation of various grafts in dogs showed medium-porosity knitted Dacron to have better endothelial coverage, perigraft attachment, and thrombus-free surface than collagenimpregnated knitted Dacron. 23 It is possible that the bovine collagen found in collagen-impregnated knitted Dacron grafts does not experience the "washout" of collagen in the carotid artery as fast as it does in a large-diameter high-flow conduit such as an aortic graft. Several authors have shown in animal experimental models that Dacron prostheses have different characteristics when placed in the thoracic and abdominal aorta 24 and in the carotid and femoral sites.…”

Section: Discussionmentioning

confidence: 99%

Prospective randomized trial of ACUSEAL (Gore-Tex) vs Finesse (Hemashield) patching during carotid endarterectomy: Long-term outcome

AbuRahma

Stone

Elmore

et al. 2008

Journal of Vascular Surgery

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“…4 "" 6 Recent reports describing the early failure of collagen-impregnated grafts implanted as extra cardiac conduits, secondary to excessive tissue reaction has generated some concern over the possible immune-stimulating effect of these prostheses. 78 Cross-linking agents such as formaldehyde and glutaraldehyde are cytotoxic substances that may stimulate the immune system by causing monomer dispersion in the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

In VivoBiocompatibility and Degradation Studies of Polyhydroxyoctanoate in the Rat: A New Sealant for the Polyester Arterial Prosthesis

et al. 1999

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The present study examined the biocompatibility and degradation properties of poly (beta-hydroxy octanoate) (PHO) as an impregnation substrate on arterial prostheses. PHO-impregnated polyester grafts sterilized by ethylene oxide (EO) or gamma (gamma) radiation, and polyester Dacron(R) prostheses impregnated with fluoropolymer, gelatin, or albumin were implanted subcutaneously in rats for periods ranging from 2 to 180 days. The biocompatibility was assessed by quantifying the alkaline and acid phosphatase secretion while performing histological studies at the tissue/prosthesis interface. The degradation was determined by chemical analysis of the EO and gamma-sterilized PHO after implantation using differential scanning calorimetry (DSC), wide angle x-ray diffraction (WAXD), and size exclusion chromatography (SEC). Alkaline phosphatase activity by the sterilized PHO and by the gelatin and albumin grafts was significantly elevated early after implantation in contrast to that of the Dacron and fluoropolymer grafts that occurred later, at 7 and 5 days, respectively The peak of acid phosphatase activity for all of the grafts occurred between 5 and 10 days postimplantation, with the gamma-sterilized PHO grafts recording the greatest activity. Histological study revealed that the tissue incorporation into the graft wall was earlier and more complete for the Dacron and fluoropolymer grafts after 6 months than for the gelatin and albumin grafts, because the latter induced important inflammatory reactions during the resorption of the cross-linked protein substrates. The EO and gamma-sterilized PHO grafts exhibited a similar healing sequence characterized by the development of a collagenous tissue surrounding the prostheses. However, no infiltration of tissue into the graft wall was observed after 6 months, mainly because of the presence of the PHO. Degradation of the EO and gamma-sterilized PHO occurred preferentially by a hydrolytic mechanism as shown by a 30% molecular weight decrease after 6 months. In conclusion, PHO showed good biocompatibility in terms of enzyme activity and tissue reaction. Degradation was a slow, in vivo process controlled primarily by a random hydrolytic reaction and by a local enzymatic attack by macrophages and giant cells.

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Experimental Evaluation of Ten Clinically Used Arterial Prostheses

Cited by 38 publications

References 6 publications

Vascular graft healing. III. FTIR analysis of ePTFE graft samples from implanted bigrafts

Vascular graft healing. III. FTIR analysis of ePTFE graft samples from implanted bigrafts

Prospective randomized trial of ACUSEAL (Gore-Tex) vs Finesse (Hemashield) patching during carotid endarterectomy: Long-term outcome

In VivoBiocompatibility and Degradation Studies of Polyhydroxyoctanoate in the Rat: A New Sealant for the Polyester Arterial Prosthesis

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