Experimental chorioretinitis in rabbits following injection of autologous retina in Freund's complete adjuvant

Hempel, E; Tilgner, S.; Meyer, Wolfgang; Schröder, K. D.

doi:10.1016/0014-4835(76)90167-6

Cited by 7 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental allergic uveitis (EAU) can be induced in rabbits by administering retina (Hempel et al, 1976) or soluble retinal S-antigen (Kalsaw and Wacker, 1986;Rao et al, 1986;Fricke et aI., 1990) and complete Freund's adjuvant; 90% of animals develop a chorioretinitis characterized by spontaneous relapses. Immunization with bovine interphotoreceptor retinoidbinding protein (IRBP) will result in a uveoretinitis with macrophagic infiltrate, outer retinal degeneration, and breakdown of the blood-retinal barrier notable by day 18 (Eisenfeld et at., 1987).…”

Section: Uveitismentioning

confidence: 99%

Models in Ophthalmology and Vision Research

Peiffer¹,

Pohm-Thorsen²,

Corcoran³

1994

The Biology of the Laboratory Rabbit

View full text Add to dashboard Cite

Section: Uveitismentioning

confidence: 99%

Models in Ophthalmology and Vision Research

Peiffer¹,

Pohm-Thorsen²,

Corcoran³

1994

The Biology of the Laboratory Rabbit

View full text Add to dashboard Cite

“…Aronson and co-workers (1963a,b,c) demonstrated that uveal preparations from albino guinea pigs are antigenic, suggesting that melanin is not a vital antigenic component of the disease process. A number of workers have demonstrated that antigens from the rod outer segments and retinal pigment epithelium can induce experimental allergic uveitis in primates, guinea pigs, and rabbits (Wong et al, 1975;Meyers and Pettit, 1975;Hempel et al, 1976). While previous workers had demonstrated that crude extracts of uveal tissue can also produce EAU, Faure et al (1977) have suggested that the activity observed with these uveal preparations was probably due to contamination by retinal antigens, and most investigators accept their hypothesis that retinal antigens are more important than uveal antigens in EAU.…”

Section: Animal Models Of Noninfectious Uveitismentioning

confidence: 99%

Animals in Ophthalmic Research: Concepts and Methodologies

Peiffer¹,

Armstrong²,

Johnson³

1981

Methods of Animal Experimentation

View full text Add to dashboard Cite

The aicardi syndrome: Report of 4 cases and review of the literature

Bertoni

Loh

Allen

1979

Annals of Neurology

View full text Add to dashboard Cite

The findings i n 4 cases of A i c a r d i s y n d r o m e (female infants w i t h mental retardation, seizures, characteristic e y e lesions, agenesis o f the c o r p u s callosum, vertebral anomalies. and a b n o r m a l b u t nondiagnostic electroencephalog r a p h i c patterns) are c o m p a r e d to 39 previously reported cases. Available information suggests that t h e s y n d r o m e results f r o m an u n k n o w n i n t r a u t e r i n e insult o c c u r r i n g no later t h a n the first trimester. No familial cases have been reported, and the cause remains u n k n o w n . Case Reports Patierit 1An infant girl was the product of an unremarkable gestation (except for transient skin rash and albuminuria) and delivery. At birth, severe right microphthalmia and dysplasia o f the left retina were noted. At 2 weeks of age the baby developed spells of eye rolling, eyelid twitching, extension of the extremities. and mild cyanosis. Roentgenograms demonstrated normal skull and forearms but multiple thoracic vertebral anomalies. T h e head progressively enlarged, and a ventriculogram showed agenesis of the corpus callosum and multiple cortical heterotopias. An electroencephalogram was moderately abnormal with a paroxysmal epileptogenic focus in the left hemisphere. At 3 months of age a ventriculoatrial shunt was inserted due to increasing head size.At the age of 29 months, a follow-up examination revealed an unresponsive child in decerebrate posture with torticollis and poor handling of oral secretions. There was generalized chorioretinitis o n the left. T h e electroencephalogram was profoundly abnormal, with a burst-suppression pattern. Patient 2An infant girl was the product of a term pregnancy marked by "stomach cramps," headaches, and vaginal discharge. Labor was induced 48 hours after rupture of the membranes. At 10 weeks, the patient began to have headbobbing spells up to 100 times per day, with tonic-clonic movements and eye deviation to the left. Right microphthalmia and extensive bilateral chorioretinitis f Fig l I were seen. Roentgenograms showed brachycephaly and variations in size of the lumbar vertebrae. A pneumoencephalogram revealed agenesis of the corpus callosum and heterotopias adjacent to dilated lateral ventricles. The EEG was markedly and diffusely abnormal, with frequent spike-wave and polyspike-wave bursts consistent with hypsarrhythmia and a burst-suppression pattern. T h e seizures persisted despite a regimen of phenobarbital, 3 0 mg daily, phenytoin, 15 mg daily, and prednisone, 1 5 mg daily. Putierit 3A term female infant required forceps delivery after 32 hours of labor. At 1 1 weeks she developed daily convulsions consisting o f cyclic flexion o f the extremities for several seconds; these convulsions were not controlled with phenobarbital, 40 mg per day. At 14 weeks, examination revealed normocephaly, bilateral chorioretinitis. right exorropia, and hypotonia. Roentgenograms showed a normal skull but multiple thoracic spinal anomalies. A

show abstract

Experimental chorioretinitis in rabbits following injection of autologous retina in Freund's complete adjuvant

Cited by 7 publications

References 15 publications

Models in Ophthalmology and Vision Research

Models in Ophthalmology and Vision Research

Animals in Ophthalmic Research: Concepts and Methodologies

The aicardi syndrome: Report of 4 cases and review of the literature

Contact Info

Product

Resources

About