Experimental Cholesteatoma:<i>Epidermal Ingrowth through Tympanic Membrane following Middle Ear Application of Propylene Glycol</i>

Masaki, Masami; Wright, Charles G.; Lee, David H.; Meyerhoff, William L.

doi:10.3109/00016488909107401

Cited by 40 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the squamous immigration theory, the epithelium of the lateral surface migrates through a perforation at the margin of the TM to enter the middle ear cavity. In animal models, squamous epithelium can be made to migrate medially through a marginal perforation . An essential difficulty with this theory is that, given the incidence of TM perforation, cholesteatomas are relatively rare.…”

Section: Resultsmentioning

confidence: 99%

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Early changes in experimental cholesteatoma production have been demonstrated by several investigators. Masaki et al 7 showed that 2 days after the application of propylene glycol into the middle ear the outer squamous epithelial and inner mucosal layers of the tympanic membrane were completely destroyed and within a week a hyperplastic epithelium completely covered the tympanic membrane. If the inflammation within the middle ear continued, this hyperplastic epithelium migrated through the intact lamina propria into the middle ear, where it keratinized to produce cholesteatoma.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intratympanic Steroid Application on the Development of Experimental Cholesteatoma

et al. 1998

View full text Add to dashboard Cite

By introducing certain irritants into the middle ear it is possible to produce cholesteatoma. Propylene glycol, the main agent used for this purpose, produces a long-standing inflammation that causes hyperplasia and migration of the epithelium through an intact tympanic membrane. In the present investigation topical prednisolone was used in order to inhibit the production of cholesteatoma. The results indicate that there is a marked decrease in inflammation and hence experimental cholesteatoma production when prednisolone is administered into the middle ear.

show abstract

“…1) The "migration theory" postulates relocation of squamous epithelium from the margin of a perforated or retracted TM into the middle ear, forming a cholesteatoma. 20 2) The "basal hyperplasia theory" assumes an inflammationassociated proliferation of basal cells breaking through the basement membrane, thus giving rise to a cholesteatoma. 21 3) The "postsurgery/posttraumatic theory" claims iatrogenic implantation of epidermal elements into the middle ear cavity.…”

Section: Pathophysiologymentioning

confidence: 99%

Neuroradiology of Cholesteatomas

Baráth¹,

Huber²,

Stämpfli³

et al. 2010

AJNR Am J Neuroradiol

178

141

View full text Add to dashboard Cite

SUMMARY:The relevant aspects of cholesteatomas are reviewed with the emphasis on their diagnosis by using cross-sectional imaging. The indications and limitations of CT and MR imaging and the use of novel MR imaging techniques in the diagnosis of cholesteatomas are described. HRCT of the temporal bone has an excellent spatial resolution, thus even small soft-tissue lesions can be accurately delineated (high sensitivity). However, CT has poor specificity (ie, soft-tissue structures cannot be differentiated). MR imaging with the conventional sequences (T1WI, T2WI, postcontrast T1WI) provides additional information for distinguishing different pathologic entities and for accurately diagnosing primary (nonsurgical) and residual/recurrent (surgical) cholesteatomas. Higher diagnostic specificity is achieved by introducing DW-EPI, delayed postcontrast imaging, DW-non-EPI, and DWI-PROPELLER techniques. Studies using DW-non-EPI and DWI-PROPELLER sequences show promising results related to improved diagnostic sensitivity and specificity for even small (Ͻ5 mm) cholesteatomas, thus allowing avoidance of second-look surgery in the future.ABBREVIATIONS: DWI ϭ diffusion-weighted imaging; DW-EPI ϭ diffusion-weighted echo-planar imaging; DWI-PROPELLER ϭ diffusion-weighted imaging with periodically rotated overlapping parallel lines with enhanced reconstruction; DW-non-EPI ϭ diffusion-weighted non-echo-planar imaging; EAC ϭ external auditory canal; EACC ϭ external auditory canal cholesteatoma; EPI ϭ echo-planar imaging; FIESTA ϭ fast imaging employing steady-state acquisition; FLASH ϭ fast low-angle shot; HRCT ϭ high-resolution CT; NPV ϭ negative predictive value; PPV ϭ positive predictive value; T1WI ϭ T1-weighted imaging; T2WI ϭ T2-weighted imaging; TM ϭ tympanic membrane C holesteatoma has been known for more than 300 years in the medical literature; still its precise detection with the use of cross-sectional imaging techniques remains challenging. As before, the diagnosis of a cholesteatoma at first presentation is mainly based on clinical suspicion. HRCT provides information about bony changes and intracranial complications; however, it is inaccurate for characterizing the soft-tissue mass in the temporal bone. In the past 7 years, improvements in MR imaging techniques have enhanced the sensitivity and specificity of radiologic diagnosis, which may lead to future avoidance of second-look surgeries in cases of residual/recurrent cholesteatomas.The purpose of this review article is to summarize all aspects of cholesteatomas, including their definition, history, etymology, epidemiology, classification, histology, pathophysiology, clinical signs, and neuroradiologic diagnosis. We review the latest studies on the application of new MR imaging techniques for the accurate diagnosis of cholesteatomas. Definition"Cholesteatoma" is a well-demarcated non-neoplastic lesion in the temporal bone, which is commonly described as "skin in the wrong place." History and EtymologyJoseph-Guichard Duverney, a French anatomist, was the first to d...

show abstract

Experimental Cholesteatoma:Epidermal Ingrowth through Tympanic Membrane following Middle Ear Application of Propylene Glycol

Cited by 40 publications

References 9 publications

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

Effect of Intratympanic Steroid Application on the Development of Experimental Cholesteatoma

Neuroradiology of Cholesteatomas

Contact Info

Product

Resources

About