Effect of Intratympanic Steroid Application on the Development of Experimental Cholesteatoma

Abstract

By introducing certain irritants into the middle ear it is possible to produce cholesteatoma. Propylene glycol, the main agent used for this purpose, produces a long-standing inflammation that causes hyperplasia and migration of the epithelium through an intact tympanic membrane. In the present investigation topical prednisolone was used in order to inhibit the production of cholesteatoma. The results indicate that there is a marked decrease in inflammation and hence experimental cholesteatoma production when prednisolone is administered into the middle ear.

Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats

“…In the current study, cholesteatoma was induced by intratympanic injection via the tympanic membrane, in a model in which down-regulation of fibroblast action was expected due to mitomycin C. The cholesteatoma frequency in the control group was similar to previously published figures, i.e. 33–90 per cent 12 , 13 , 17 , 18 . In the current study, there was no significant difference in cholesteatoma development between the two groups ( p = 0.687) (Table IV).…”

Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation

“…If there is ongoing middle-ear inflammation, the hyperplastic epidermis of the tympanic membrane migrates through the intact tympanic membrane, reaches the middle ear, continues proliferating and, after keratinisation, forms the cholesteatoma matrix. According to this papillary ingrowth model, pathogenesis proceeds without retraction pockets or tympanic membrane perforation 8 . Although most studies have administered propylene glycol via the bulla, intratympanic administration can induce similar rates of cholesteatoma formation: bulla administration of propylene glycol is reported to cause cholesteatoma formation rates of 0–90 per cent, 5 – 12 while the only previous study to use intratympanic administration reported a rate of 63.6 per cent 7 .…”

Tumors of the skull base in children: review of tumor types and management strategies

“…107,142 Intratympanic prednisolone has also been found to decrease experimental cholesteatoma production. 116 Other investigated agents include hyaluronic acid and cyclophosphamide, but no success has been observed. …”