Experimental canine leishmaniasis: evolution of infection following re-challenge with Leishmania infantum

Santos‐Gomes, Gabriela; Capela, M.; Ramada, João; Campino, Lenea

doi:10.1016/s0001-706x(03)00023-8

Cited by 13 publications

(5 citation statements)

References 33 publications

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“…Cell proliferation is expressed as a stimulation index (SI), which is obtained by the ratios of stimulated cells to non-stimulated cells). SI ≥ 2 are considered positive (Cabral et al, 1992 , 1998 ; Pinelli et al, 1994 ; Leandro et al, 2001 ; Quinnell et al, 2001a ; Fernández-Pérez et al, 2003 ; Santos-Gomes et al, 2003 ; Fernández-Bellón et al, 2005 ). Asymptomatic and resistant dogs present a strong proliferative response to leishmanial antigens while susceptible and diseased animals fail to respond respectively, to SLA and to mitogen (Abranches et al, 1991 ; Pinelli et al, 1994 ; Rhalem et al, 1999 ; Quinnell et al, 2001a ; Strauss-Ayali et al, 2005 ).…”

Section: Cellular Biomarkers To Leishmania Infantum mentioning

confidence: 99%

Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

Maia

Campino

2018

Front. Cell. Infect. Microbiol.

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Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan Leishmania (Leishmania) infantum species [syn. L. (L.) infantum chagasi species in the Americas] which is transmitted by the bite of a female phlebotomine sand fly. This parasitosis is endemic and affect millions of dogs in Asia, the Americas and the Mediterranean basin. Domestic dogs are the main hosts and the main reservoir hosts for human zoonotic leishmaniosis. The outcome of infection is a consequence of intricate interactions between the protozoan and the immunological and genetic background of the host. Clinical manifestations can range from subclinical infection to very severe disease. Early detection of infected dogs, their close surveillance and treatment are essential to control the dissemination of the parasite among other dogs, being also a pivotal element for the control of human zoonotic leishmaniosis. Hence, the identification of biomarkers for the confirmation of Leishmania infection, disease and determination of an appropriate treatment would represent an important tool to assist clinicians in diagnosis, monitoring and in giving a realistic prognosis to subclinical infected and sick dogs. Here, we review the recent advances in the identification of Leishmania infantum biomarkers, focusing on those related to parasite exposure, susceptibility to infection and disease development. Markers related to the pathogenesis of the disease and to monitoring the evolution of leishmaniosis and treatment outcome are also summarized. Data emphasizes the complexity of parasite-host interactions and that a single biomarker cannot be used alone for CanL diagnosis or prognosis. Nevertheless, results are encouraging and future research to explore the potential clinical application of biomarkers is warranted.

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Section: Cellular Biomarkers To Leishmania Infantum mentioning

confidence: 99%

Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

Maia

Campino

2018

Front. Cell. Infect. Microbiol.

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“…In fact, a previous study in experimental canine leishmaniasis, after re-challenge with L. infantum promastigotes, suggests that resistance to Leishmania might be achieved when associated to the induction of a host immune memory response [36].…”

Section: Discussionmentioning

confidence: 99%

Dynamics of CD62L/CD45RB CD4+ and CD8+ lymphocyte subsets in hepatic and splenic tissues during murine visceral leishmaniasis

2004

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“…É também observada uma forte correlação entre o aparecimento da clínica e a perda da resposta proliferativa antígeno específica . A apresentação clínica da leishmaniose é consequência da interação entre o parasito e a resposta imunológica do hospedeiro (Chamizo, Moreno & Alvar, 2005), e o resultado da infecção depende principalmente da imunocompetência do animal que, em última análise, leva o macrófago a destruir o parasito (Chamizo, Moreno & Alvar, 2005;Ferrer, 1999;Santos-Gomes et al, 2003).…”

Section: Caninounclassified

“…No que se refere à forma infectante, alguns autores (Campino et al, 2000;Santos-Gomes et al, 2003) consideram que cães experimentalmente infectados com amastigotas desenvolvem infecção sintomática, enquanto os infectados com promastigotas desenvolvem infecção assintomática, embora com alterações hematológicas e proteicas. Entretanto, diversos estudos (Pinelli et al, 1994;Martínez-Moreno et al, 1995;Carrera et al, 1996;Nieto et al, 1999;Rhalem et al, 1999;Leandro et al, 2001; não corroboram esta ideia.…”

Section: Caninounclassified

Leishmanioses do continente americano

Conceição-Silva¹,

Alves²

2014

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Experimental canine leishmaniasis: evolution of infection following re-challenge with Leishmania infantum

Cited by 13 publications

References 33 publications

Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

Dynamics of CD62L/CD45RB CD4+ and CD8+ lymphocyte subsets in hepatic and splenic tissues during murine visceral leishmaniasis

Leishmanioses do continente americano

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