Experimental assessment of carbacetam effect on the cerebral mitochondria in rats with scopolamine-induced Alzheimer’s disease

Kmet, O. G.; Filipets, N. D.; Yaremii, І.М.; Kmet, T. I.; VEPRIUK, Yurii M.; HRACHOVA, Tamara I.

doi:10.31688/abmu.2020.55.1.01

Cited by 2 publications

(3 citation statements)

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“…Two reviewers independently assessed the risk of bias using the 14-item standard quality assessment for evaluating primary research articles from a variety of fields . Total scores range from 0 to 1, 0 indicating the lowest and 1 the highest quality.…”

Section: Methodsmentioning

confidence: 99%

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Diabetic Retinopathy and Quality of Life

Zayed,

Karsan,

Peto

et al. 2024

JAMA Ophthalmol

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ImportanceThe association between diabetic retinopathy (DR) and quality of life (QoL) has not been thoroughly investigated.ObjectiveTo investigate the association between DR and both vision-related QoL (VRQoL) and general health-related QoL (HRQoL).Data SourcesMEDLINE, EBSCO, Embase, and Web of Science were searched from their inception to April 2022.Study SelectionStudies included adults with DR and a measure of QoL.Data Extraction and SynthesisPreferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Two assumption-free meta-analyses were conducted. Analysis 1 included studies with participants without DR as the referent group to which QoL scores of participants with DR, grouped according to DR severity, were compared. Analysis 2 included all studies with participants with DR and a measure of QoL. QoL scores were pooled within categories of DR severity, and comparisons were made between these categories.Main Outcome and MeasuresQoL measured using HRQoL and VRQoL scales.ResultsA total of 93 articles were included: 79 in the meta-analyses and 14 in the narrative results. VRQoL was recorded in 54 studies, HRQoL in 26, and both in 13 studies. The most commonly used scales were the National Eye Institute 25-item Visual Function Questionnaire (VFQ-25) (n = 49) for VRQoL and the Short Form (SF) Health Survey (n = 18) for HRQoL. Thirty-five studies reported VFQ-25 composite scores. Analysis 1 consisted of 8 studies including 1138 participants with DR and 347 participants without DR. Compared with participants without DR, the composite VFQ-25 score was 3.8 (95% CI, 1.0-6.7) points lower in those with non–vision-threatening DR (NVTDR), 12.5 (95% CI, 8.5-16.5) lower in those with any DR, and 25.1 (95% CI, 22.8-27.2) lower in VTDR (P &lt; .001 for trend). Analysis 2 consisted of 35 studies including 6351 participants with DR. The pooled mean VFQ-25 composite score was 91.8 (95% CI, 91.0-92.7) for participants with NVTDR, 77.6 (95% CI, 76.9-78.3) for any DR, and 73.2 (95% CI, 72.6-73.7) for VTDR (P &lt; .001 for trend). HRQoL scores had weak or no associations with NVTDR and strong associations with VTDR.Conclusions and RelevanceThis study found that VRQoL declined with the presence and severity of DR. Interventions to reduce progression of DR at both early and more advanced stages could improve VRQoL.

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Section: Methodsmentioning

confidence: 99%

“…Total scores range from 0 to 1, 0 indicating the lowest and 1 the highest quality. Studies scoring more than 0.75 were considered to represent high quality . Disagreements were resolved by discussion or by a third reviewer.…”

Section: Methodsmentioning

confidence: 99%

Diabetic Retinopathy and Quality of Life

Zayed,

Karsan,

Peto

et al. 2024

JAMA Ophthalmol

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“…Mixed-effects meta-regression models were used to evaluate whether potential continuous confounders were associated with effort-cost decision-making performance in the schizophrenia group, including the age of participants, negative symptoms, antipsychotic dosage measured in CPZ equivalent, proportion of atypical antipsychotics, proportion of trials completed, and the methodologic quality of studies as measured by the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields total score.…”

Section: Methodsmentioning

confidence: 99%

Effort-Cost Decision-making Among Individuals With Schizophrenia

et al. 2023

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ImportanceMotivational impairments in schizophrenia are by definition associated with poor outcome. It is postulated that the reduction of goal-directed behavior arises from abnormal trade-offs between rewards and efforts.ObjectiveTo examine whether schizophrenia is associated with impairments in effort-cost decision-making.Data SourcesFor this systematic review and meta-analysis, the PubMed, ScienceDirect, PsycINFO, Embase, and ClinicalTrials.gov databases were searched from inception to July 2022 for studies that investigated effort-cost decision-making in schizophrenia. Search terms included effort, cost, and schizophrenia.Study SelectionConsensual criteria for inclusion were peer-reviewed studies published in English that used a computerized effort-cost decision-making behavioral paradigm and compared individuals with schizophrenia with control individuals.Data Extraction and SynthesisThe Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was used for abstracting data. Data were extracted independently by 2 authors and then pooled using random-effects sizes and bayesian approaches.Main Outcomes and MeasuresThe main outcomes were performance on effort-cost decision-making tasks requiring an effort-reward trade-off, measured by Hedges g effect size. Effects of moderators were tested with meta-regressions and subgroup analyses.ResultsTwenty studies involving 1503 participants were included: 837 individuals with schizophrenia (541 [64.6%] male; mean [SD] age, 35.89 [6.70] years) and 666 control individuals without schizophrenia (360 [54.1%] male; mean [SD] age, 34.16 [5.92] years). Participants with schizophrenia had significantly reduced willingness to expend effort for rewards compared with controls (k = 20; effect size, 0.43; 95% CI, 0.30-0.56; P &lt; .001; I2 = 33.1%; Q test P = .08). The magnitude of the deficit was significantly greater for high-reward trials. The severity of negative symptoms was negatively associated with effort-cost decision-making (k = 8; effect size, −0.33; 95% CI, −0.50 to −0.15; P &lt; .001), while participants with a high number of negative symptoms had a significantly larger impairment in effort-cost decision-making (k = 5; effect size, 0.47; 95% CI, 0.10-0.84; P = .01).Conclusions and RelevanceIn this systematic review and meta-analysis, schizophrenia was associated with deficits in effort allocation as indexed by effort-cost decision-making tasks. Understanding the cognitive and neurobiological mechanisms driving effort allocation impairments may assist in developing novel interventions.

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Experimental assessment of carbacetam effect on the cerebral mitochondria in rats with scopolamine-induced Alzheimer’s disease

Cited by 2 publications

References 14 publications

Diabetic Retinopathy and Quality of Life

Diabetic Retinopathy and Quality of Life

Effort-Cost Decision-making Among Individuals With Schizophrenia

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