Experimental and thermodynamic investigation of gemifloxacin solubility in supercritical CO2 for the production of nanoparticles

Arabgol, Fatemeh; Amani, Mitra; Saadati Ardestani, Nedasadat; Sajadian, Seyed Ali

doi:10.1016/j.supflu.2023.106165

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…A successful self-consistency test is indicated by all solubility data calculated by the models forming a nearly straight line, typically at an approximate angle of 45°. As conducted by other researchers, , a self-consistency test was carried out in this study for the Chrastil, Bartle, MST, and Jafari Nejad models, which have been successfully utilized to correlate the zolpidem solubility in scCO 2 . As depicted in Figure , these models have successfully passed this analysis.…”

Section: Results and Discussionmentioning

confidence: 99%

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Alhuwaymil,

Alsolami,

Almisbahi

et al. 2024

J. Chem. Eng. Data

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Obtaining data on the solubility of zolpidem, a sedative−hypnotic drug, in supercritical CO 2 (scCO 2 ) is a crucial step in the development of an efficient supercritical process designed to formulate an effective drug delivery system for this medication. The current investigation entailed determining the solubility of this substance in scCO 2 across a range of temperatures (308.0, 318.0, 328.0, 338.0, and 348.0 K) and pressure values between 17 and 41 MPa. Furthermore, the research delved into assessing the impact of two cosolvents, DMSO and ethanol, on the supercritical solubility of this drug under the given conditions. The solubility of zolpidem in scCO 2 was within the mole fraction range of 1.19 × 10 −4 −3.23 × 10 −4 . However, when ethanol and DMSO were introduced, the solubilities were enhanced to the ranges of 3.09 × 10 −4 −22.13 × 10 −4 and 1.31 × 10 −4 −12.44 × 10 −4 , respectively. It was noted that the impact of ethanol is more substantial, leading to an approximately 4−5 times improvement in the supercritical solubility of zolpidem. Utilizing validated empirical models to correlate supercritical solubility data for both the scCO 2 −zolpidem and scCO 2 −ethanol−zolpidem systems, it was observed that the empirical models developed by Nejad and Keshmiri for the zolpidem−scCO 2 system (AARD% ≈ 1.50 and R adj = 0.996) and by MST−Sauceau for the zolpidem−scCO 2 −ethanol system (AARD% = 3.51 and R adj = 0.995) exhibited the highest levels of consistency between the predicted solubility values and the actual experimental data. Also, the supercritical solubility data of the scCO 2 −zolpidem binary system were evaluated by using the SRK and UNIQUAC models. It was observed that the SRK model demonstrated exceptional accuracy (AARD% = 1.53 and R adj = 0.999) in modeling zolpidem solubility in scCO 2 .

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Section: Results and Discussionmentioning

confidence: 99%

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Alhuwaymil,

Alsolami,

Almisbahi

et al. 2024

J. Chem. Eng. Data

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“…Noteworthily, a crossover point occurs at about 180 bar. As mentioned in previous publications [66,[84][85][86], there are two competing effects as temperature increases: a linear decrease in density versus an exponential increase in sublimation pressure. Therefore, beyond 180 bar, the exponential increase of the sublimation pressure with temperature dominates over the density effect and, thus, the solubility is higher at higher temperatures.…”

Section: Experimental Datamentioning

confidence: 96%

“…A detailed explanation of the solubility in scCO 2 measurement is documented elsewhere [39,[66][67][68][69][70][71][72], and a brief explanation of this process is provided in the Supporting Information file. The Table 1.…”

Section: Experimental Apparatusmentioning

confidence: 99%

Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Sajadian,

Esfandiari,

Saadati Ardestani

et al. 2024

Chem Eng & Technol

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Mebeverine hydrochloride is an important drug to treat irritable bowel syndrome. The solubility of this drug in supercritical carbon dioxide was measured at temperatures from 35 to 65 °C and pressures from 12 to 30 MPa. Results were between 2.16 and 30.2 ppm by mole. The data were correlated with density‐based models (K‐J, MST, Chrastil, Garlapati and Madras, Bartle et al., and Sparks et al.) and equations of state (Peng‐Robinson, Soave, and Estévez et al. models). The mean relative deviation and corrected correlation coefficient were used to assess the goodness of the models. Based on all ten models, Sparks et al. performed best according to average absolute relative deviation (5.64 %), and Bartle et al. was the best according to Radj (0.997). However, this contribution's main merit is the reported experimental data.

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“…The empirical models represent the initial and straightforward models extensively utilized to correlate the supercritical solubility of a variety of materials in binary and triple supercritical systems. Numerous researchers have previously validated the accuracy and reliability of these models in correlating supercritical solubility data for diverse compounds. ,− …”

Section: Experimental Partmentioning

confidence: 99%

Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO₂: Experimental Analysis and Artificial Intelligence Study

Alsawad,

Mohammad AlHamad,

Rodriguez-Benites

et al. 2024

J. Chem. Eng. Data

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Assessing the solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO 2 ) is a fundamental prerequisite for advancing the application of supercritical technologies in the pharmaceutical sector. The supercritical solubility of Febuxostat, a drug with limited solubility often prescribed for gout patients to lower blood uric acid levels, has previously been studied within the pressure and temperature ranges of 12−27 MPa and 308−338 K, exhibiting a mole fraction range of 0.05 × 10 −4 −7.42 × 10 −4 . This study explores the influence of various cosolvents, namely, ethanol, acetone, and dimethyl sulfoxide (DMSO), on the supercritical solubility of Febuxostat under comparable conditions. Results indicate solubility within the mole fraction range of 0.180 × 10 −4 −26.658 × 10 −4 for ethanol, 0.120 × 10 −4 −14.810 × 10 −4 for acetone, and 0.108 × 10 −4 −14.366 × 10 −4 for DMSO, respectively. Ethanol exhibits the most substantial impact, enhancing the supercritical solubility of Febuxostat by approximately 2.4−3.8 times, while acetone and DMSO contribute to an increase of approximately 2−2.5 times. Furthermore, the study employs empirical models and an artificial neural network (ANN) approach to theoretically investigate the supercritical solubility of Febuxostat with these cosolvents. Among the empirical models, the Jouyban model demonstrates the most accurate correlation for the solubility data of all cosolvents. Moreover, the ANN model demonstrates exceptional accuracy in forecasting the solubility of Febuxostat, with a mean AARD % of 3.207% and R adj of 0.993 across all experimental measurements for Febuxostat solubility in scCO 2 + ethanol, scCO 2 + acetone, and scCO 2 + DMSO solvents.

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Experimental and thermodynamic investigation of gemifloxacin solubility in supercritical CO2 for the production of nanoparticles

Cited by 7 publications

References 70 publications

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO₂: Experimental Analysis and Artificial Intelligence Study

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Experimental and thermodynamic investigation of gemifloxacin solubility in supercritical CO2 for the production of nanoparticles

Cited by 7 publications

References 70 publications

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Measurement and Modeling of Zolpidem Solubility in Supercritical Carbon Dioxide: Effect of Two Cosolvents

Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO2: Experimental Analysis and Artificial Intelligence Study

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Product

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Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO₂: Experimental Analysis and Artificial Intelligence Study