Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO2: Experimental Analysis and Artificial Intelligence Study
Oday Sajjad Alsawad,
Ahmad Qasim Mohammad AlHamad,
Carlos Rodriguez-Benites
et al.
Abstract:Assessing the solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO 2 ) is a fundamental prerequisite for advancing the application of supercritical technologies in the pharmaceutical sector. The supercritical solubility of Febuxostat, a drug with limited solubility often prescribed for gout patients to lower blood uric acid levels, has previously been studied within the pressure and temperature ranges of 12−27 MPa and 308−338 K, exhibiting a mole fraction range of 0.05 × 10 −4 −7.42 × 1… Show more
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