“…In fact, Simunic et al [44] verified that in dead-end zones, fouling was not affected by fluid flushing (high turbulence from high fluid velocity) that was typical for the main pipe. Several studies identified critical areas for fouling formation such as the regions closed to corners and baffles [59,75,104] and header section [102] in HE, regions closed to expansions/contractions [110,120], angles [128,134], elbows [112,133], and valves [12,114] in distribution networks, and regions closed to corners in the bottom [154], and baffles in the tank wall [165] in STRs. In addition of being prone for fouling phenomena, dead-end zones affect CIP efficacy, compromising the process and product quality, and increase operating and maintenance costs [12].…”