Experimental and computational investigation of two-component mixtures for the alkyl (ethyl, propyl and butyl) oleate in supercritical carbon dioxide

Dhamodharan, Duraisami; Park, Cheolwoong; Ghoderao, Pradnya NP; Byun, Hun‐Soo

doi:10.1016/j.jiec.2022.03.013

Cited by 15 publications

(3 citation statements)

References 32 publications

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“…2) and methods employed to determine the PB of the 355-TMHA and 335-TMCHMA monomers in Sc-CO 2 are depicted in depth elsewhere. [22][23][24][25][26][27][28][29][30] A 3 V cell was employed to assess the PB that controlled the pressure maximum at 200.0 MPa. Normally, CO 2 was introduced into the 3 V cell, within AE0.002 g with the aid of high-pressure equipment.…”

Section: Equipment and Proceduresmentioning

confidence: 99%

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

2023

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Section: Equipment and Proceduresmentioning

confidence: 99%

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

2023

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“…Thermodynamic models are well-suited for macroscopic-scale descriptions of the thermodynamic behavior and phase transitions of a system, particularly when it involves variations in temperature and pressure. They can be used to calculate drug solubility, density, and phase behavior in SCCO 2 [44][45][46].…”

Section: Eos-based Modelsmentioning

confidence: 99%

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Huang,

Zheng,

et al. 2023

Bioengineering

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In recent years, nanomedicines prepared using supercritical technology have garnered widespread research attention due to their inherent attributes, including structural stability, high bioavailability, and commendable safety profiles. The preparation of these nanomedicines relies upon drug solubility and mixing efficiency within supercritical fluids (SCFs). Solubility is closely intertwined with operational parameters such as temperature and pressure while mixing efficiency is influenced not only by operational conditions but also by the shape and dimensions of the nozzle. Due to the special conditions of supercriticality, these parameters are difficult to measure directly, thus presenting significant challenges for the preparation and optimization of nanomedicines. Mathematical models can, to a certain extent, prognosticate solubility, while simulation models can visualize mixing efficiency during experimental procedures, offering novel avenues for advancing supercritical nanomedicines. Consequently, within the framework of this endeavor, we embark on an extensive review encompassing the application of mathematical models, artificial intelligence (AI) methodologies, and computational fluid dynamics (CFD) techniques within the medical domain of supercritical technology. We undertake the synthesis and discourse of methodologies for calculating drug solubility in SCFs, as well as the influence of operational conditions and experimental apparatus upon the outcomes of nanomedicine preparation using supercritical technology. Through this comprehensive review, we elucidate the implementation procedures and commonly employed models of diverse methodologies, juxtaposing the merits and demerits of these models. Furthermore, we assert the dependability of employing models to compute drug solubility in SCFs and simulate the experimental processes, with the capability to serve as valuable tools for aiding and optimizing experiments, as well as providing guidance in the selection of appropriate operational conditions. This, in turn, fosters innovative avenues for the development of supercritical pharmaceuticals.

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“…The relevance of the present study can be summarized as follows: (1) Advancement of supercritical fluid technology: This research contributes to our understanding of the phase behavior of binary mixtures involving supercritical CO 2 and organosilicon compounds. Such knowledge is vital for the development of supercritical fluid technologies used in various applications, including pharmaceuticals, green chemistry − and materials processing etc. − (2) Industrial processes : Improved knowledge of how these binary mixtures interact with supercritical CO 2 can lead to more efficient design and optimization industrial processes. (3) Scientific advancement : The study enhances our understanding of the phase equilibria and thermodynamics in high-pressure systems.…”

Section: Introductionmentioning

confidence: 99%

Binary Solution Behavior for the Trimethoxyphenylsilane and Trimethylphenylsilane Under CO₂ as Supercritical Fluid

Ghoderao,

Kim,

Byun

2023

Ind. Eng. Chem. Res.

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Experimental and computational investigation of two-component mixtures for the alkyl (ethyl, propyl and butyl) oleate in supercritical carbon dioxide

Cited by 15 publications

References 32 publications

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Binary Solution Behavior for the Trimethoxyphenylsilane and Trimethylphenylsilane Under CO₂ as Supercritical Fluid

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Experimental and computational investigation of two-component mixtures for the alkyl (ethyl, propyl and butyl) oleate in supercritical carbon dioxide

Cited by 15 publications

References 32 publications

High-pressure phase equilibrium of the binary systems CO2 + 355-TMHA and CO2 + 335-TMCHMA

High-pressure phase equilibrium of the binary systems CO2 + 355-TMHA and CO2 + 335-TMCHMA

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Binary Solution Behavior for the Trimethoxyphenylsilane and Trimethylphenylsilane Under CO2 as Supercritical Fluid

Contact Info

Product

Resources

About

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

High-pressure phase equilibrium of the binary systems CO₂ + 355-TMHA and CO₂ + 335-TMCHMA

Binary Solution Behavior for the Trimethoxyphenylsilane and Trimethylphenylsilane Under CO₂ as Supercritical Fluid