Experimental and clinical validation of plasmadynamic therapy of wounds with nitric oxide

Abstract

Pronounced wound-healing effect of exogenous nitric oxide obtained by the plasma chemical method was confirmed in rats with aseptic and infected wounds and in patients with complicated stubborn wounds, postradiation and trophic ulcers, necroses of transplanted skin flaps, etc. Morphological study revealed normalization of microcirculation, decreased inflammation, enhanced phagocytosis, activation of macrophages, and accelerated proliferation of fibroblasts.

Plasma‐Medizin: Anwendungsmöglichkeiten in der Dermatologie

“…A major task will be the introduction of plasma into clinical medicine and, simultaneously, the further investigation of the mechanisms of action of plasma at the cellular level. [35,36]. Unter anderem werden dafür eine Vasodilatation und normalisierte Mikrozirkulation, direkte bakterizide Effekte, Verbesserung der Nervenleitgeschwindigkeit, Stimulierung von Fibroblasten und Gefäßwachstum durch Induktion von Zytokinen und Wachstumsfaktoren verantwortlich gemacht.…”

Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations

“…On the one hand, it was recognized that the levels of nitric oxide in deep wounds and scars are reduced in comparison to its amount in healthy tissue [35][36]. In our previous investigations the high efficacy of plasma gNO therapy was observed in the treatment of radiation-induced skin fibrosis in cancer patients [6,37]. It also has been shown that plasma gNO therapy of wounds results in almost all cases in the formation of rather gentle cosmetic scars even in purulent and chronic recalcitrant lesions [38,39,40].…”

“…In previous publications [6,7] we briefly reported that the use of plasma-generated gNO provides significant therapeutic effects in treatment of several pathologies (Fig. 1).…”

“…Our previous studies [6,7] indicated that exogenous gaseous nitric oxide (gNO) flow produced by an air-plasma generator ""Plason"" acts beneficially on the wound healing. At present the therapeutic action of gNO is attributed to both direct and indirect gNO regulatory effects on inflammatory infiltration, anti-microbe macrophages activity, microcirculation and regeneration and nerve conduction.…”

“…Therapeutic effects of different plasma sources including plasma generated gaseous nitric oxide (gNO) have been utilized for various clinical applications [3][4][5][6][7]. Our previous studies [6,7] indicated that exogenous gaseous nitric oxide (gNO) flow produced by an air-plasma generator ""Plason"" acts beneficially on the wound healing.…”