Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations

Василец, В. Н.; Shekhter, Anatoly B.; Guller, Anna; Пекшев, А. В.

doi:10.1016/j.cpme.2015.05.001

Cited by 23 publications

(10 citation statements)

References 32 publications

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“…At times, specific plasma-generated species have been attributed to trigger the stimulation, modulation, or execution of the biological effects observed. Among these are hydrogen peroxide (H 2 O 2 ) 15 , 17 , atomic oxygen ( • O) 37 , or nitric oxide ( • NO) 38 and peroxynitrite (ONOO − ) 16 , 22 , 39 . Other species are harder to pinpoint, although present in high amounts in the gas phase.…”

Section: Introductionmentioning

confidence: 99%

Quantification of the ozone and singlet delta oxygen produced in gas and liquid phases by a non-thermal atmospheric plasma with relevance for medical treatment

Jablonowski

Sousa

Weltmann

et al. 2018

Sci Rep

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In the field of plasma medicine, the identification of relevant reactive species in the liquid phase is highly important. To design the plasma generated species composition for a targeted therapeutic application, the point of origin of those species needs to be known. The dominant reactive oxygen species generated by the plasma used in this study are atomic oxygen, ozone, and singlet delta oxygen. The species density changes with the distance to the active plasma zone, and, hence, the oxidizing potential of this species cocktail can be tuned by altering the treatment distance. In both phases (gas and liquid), independent techniques have been used to determine the species concentration as a function of the distance. The surrounding gas composition and ambient conditions were controlled between pure nitrogen and air-like by using a curtain gas device. In the gas phase, in contrast to the ozone density, the singlet delta oxygen density showed to be more sensitive to the distance. Additionally, by changing the surrounding gas, admixing or not molecular oxygen, the dynamics of ozone and singlet delta oxygen behave differently. Through an analysis of the reactive species development for the varied experimental parameters, the importance of several reaction pathways for the proceeding reactions was evaluated and some were eventually excluded.

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Section: Introductionmentioning

confidence: 99%

Quantification of the ozone and singlet delta oxygen produced in gas and liquid phases by a non-thermal atmospheric plasma with relevance for medical treatment

Jablonowski

Sousa

Weltmann

et al. 2018

Sci Rep

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show abstract

“…Previous work has indicated the contribution of plasma derived nitrogen species, especially nitric oxide, on experimentally or clinically observed effects. [17][18][19] Further studies showed improved wound healing by cold plasma without specifying the active players but where the role of nitric oxide is discussed. [20][21][22] Such an understanding of the deposition and/or generation processes of nitric oxide is key.…”

Section: Introductionmentioning

confidence: 99%

Non-touching plasma–liquid interaction – where is aqueous nitric oxide generated?

Jablonowski

Schmidt-Bleker

Weltmann

et al. 2018

Phys. Chem. Chem. Phys.

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“…This molecule plays an essential role in the nervous, vascular, and immune systems of the human body, for example, in relaxing smooth muscles, controlling blood flow to specific blood vessels in the heart, defensive mechanisms to fight bacteria, parasites and fungi, in vasodilation and nerve transmission, etc. 20 , 32 . It is also essential to regulate the growth and differentiation of keratinocytes 9 , which are the epidermis’ main constituents and play a defensive role against disease 20 .…”

Section: Discussionmentioning

confidence: 99%

In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation

Shakouri

Khani

Samsavar

et al. 2021

Sci Rep

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Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated on the rat skins. Also, as a new method to improve PSR results, vitamin C ointment was combined with plasma. In this study, there were four groups of 5 Wistar rats. The first group received vitamin C ointment, the second received 5 min of high-voltage plasma, and the third and the fourth groups received 5 min of high- and low-voltage plasma and vitamin C ointment. This process was done every other day (3 sessions per week) for 6 weeks. To evaluate the thermal effect of plasma, the skin temperature was monitored. Also, the presence of reactive species was demonstrated by the use of optical spectroscopy. In addition, mechanical assays were performed to assess the effect of plasma and vitamin C on the tissue’s mechanical strength. The mechanical assays showed a positive impact of plasma on the treated tissue compared to the control group. Also, changes in the collagen level and thickness of the epidermal layer were examined in histological studies. The results indicated an increase in collagen levels after using plasma alone and an accelerated skin reaction after using vitamin C combined with plasma therapy. The epidermal layer’s thickness increased after applying high-voltage plasma, which indicates an increase in skin elasticity. This study demonstrates the positive effect of using the portable plasma device with vitamin C ointment on effective parameters in skin rejuvenation.

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Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations

Cited by 23 publications

References 32 publications

Quantification of the ozone and singlet delta oxygen produced in gas and liquid phases by a non-thermal atmospheric plasma with relevance for medical treatment

Quantification of the ozone and singlet delta oxygen produced in gas and liquid phases by a non-thermal atmospheric plasma with relevance for medical treatment

Non-touching plasma–liquid interaction – where is aqueous nitric oxide generated?

In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation

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