Experimental and clinical study of the anabolic preparation silabolin

Synthetic Approaches for the Construction of Five- and Six-Membered Silaazacycles

“…In path a, the endo-cyclic Ar-Si bond migrates to give 1,2,3,4tetrahydrobenzo[e][1,3]azasilines 99. In contrast, the endocyclic CH2-Si bond migration shown in path b would give 1,2,3,4tetrahydrobenzo[b] [1,4]azasiline 100. The nature of nitrogensubstitution and the nature of the aryl ring had great impacts on the chemoselectivity.…”

“…Silabolin, a prodrug of the steroid nandrolone, was even available in Russia and used by athletes. 4 Silicon-containing molecules also form part of the commercial antifungal flusilazole and pyrethroid insecticide silafluofen, both of which are widely used in agriculture. 5 The above progresses indicate that silicon incorporation could be a valuable and safe strategy for drug discovery.…”

“…1j Silabolin, a prodrug of the steroid nandrolone, was even available in Russia and used by athletes. 4 Silicon-containing molecules also form part of the commercial antifungal flusilazole and pyrethroid insecticide silafluofen, both of which are widely used in agriculture. 5 This progress indicates that silicon incorporation could be a valuable and safe strategy for drug Given that N-heterocycles are essential core frameworks in numerous pharmaceuticals, silaazacycles, particularly those with five or six ring members, are particularly promising isosteres for the development of Si-containing bioactive molecules (Figure 1).…”